氨氯地平联合厄贝沙坦治疗糖尿病合并高血压疗效观察

Observation on curative effects of amlodipine combined with irbesartan on diabetic hypertension

目的研究氨氯地平联合厄贝沙坦对糖尿病合并高血压的疗效及对QT离散度的影响。方法选择2012年5月1日~2014年9月30日在本院就诊的2型糖尿病合并高血压患者120例为研究对象,随机分为3组各40例,对照A组给予厄贝沙坦治疗,对照B组给予苯磺酸氨氯地平治疗,观察组给予厄贝沙坦联合苯磺酸氨氯地平治疗。治疗两个月后比较3组血压水平、QT间期离散度及治疗效果。结果观察组显效率和总有效率均明显高于对照A组和B组（P〈0.05）;观察组24 h平均收缩压（24h SBP）、24 h平均舒张压（24h DBP）、24 h平均收缩压变异度（24h SBPV）、24 h平均舒张压变异度（24h DBPV）明显低于对照A组、B组（P〈0.05）;观察组的QT间期、校正QT间期、QT间期离散度均低于对照A组和对照B组（P〈0.05）。结论氨氯地平联合厄贝沙坦能够更为有效地降低糖尿病合并高血压患者血压水平和QT间期离散度,改善左心室肥厚,提高治疗效果。

Objective To study the curative effects of amlodipine combined with irbesartan on diabetic hypertension and the influence on QT dispersion. Methods 120 cases of type 2 diabetes combined with hypertension visited the hospital between May 1,2012 and September 30, 2014 were enrolled as the research objects and randomly divided into three groups with 40 ones in each group.Control group A received irbesartan, and control group B received amlodipine. Observation group received irbesartan combined with amlodipine. After 2 months of treatment, comparison was made in the blood pressure levels, QT dispersion ratio, and therapeutic effects among the three groups. Results The excellence and the total effective rate of the observation group were significantly higher than those of control group A and B（P 〈 0.05）. The 24 h SBP, 24 h DBP, 24 h SBPV, and 24 h DBPV of the observation group were significantly lower than those of control group A and B（P 〈 0.05）. The QT interval, corrected QT interval, QT interval dispersion ratio of the observation group were lower than those of the control group A and B（P 〈 0.05）. Conclusion Amlodipine combined with irbesartan can more effectively reduce blood pressure levels and QT interval dispersion of diabetic patients with hypertension, improve left ventricular hypertrophy, and improve the therapeutic effects.