某院569例药品不良反应报告的相关因素分析

Analysis of Clinical Relative Factors in 569 Cases of Adverse Drug Reactions

目的:分析沧州市人民医院药品不良反应(ADR)发生的原因与特点,为临床合理用药提供参考。方法:采用回顾性分析法,对2012年12月15日—2013年12月15日间上报的569例ADR报告采用Microsoft office Excel表格,按照引起药品不良反应患者性别、年龄、级别和给药途径、药品类别、累及器官和(或)系统及临床表现、各器官系统涉及的药品、因果关系评价、转归等因素进行分析。结果:静脉给药途径ADR发生率为最高(52.90%);心血管系统药物引起的ADR居首为29.17%,其次为抗肿瘤药为23.90%,再则为抗微生物药为11.42%;临床表现以消化系统损害为最常见(40.77%);绝大多数(40.07%)发生ADR的患者能痊愈和好转(51.32%)。结论:应加强ADR监测和报告,促进临床合理用药,以确保患者用药的安全性。

Objective： To analyze the causes and features of adverse drug reactions （ADR） in Cangzhou People＇s Hospital, and to provide a reference for clinical rational drug use. Methods： 569 ADR case reports collected from December 15, 2012 to December 15, 2013 were analyzed statistically in respect of gender, age, level and route of administration, category of the drugs, systems involved, clinical manifestation, causality and results. Results： The ADR incidence rate caused via intravenous dip （52.90%） was the highest. The ADR incidence rate （29.17%） was caused mainly by cardiovascular drugs. The ADRs were chiefly characterized by gastrointestinal lesions （40.77%）. Most of ADR patients can be cured （40.07%）or improved （51.32%）. Conclusion ADR monitoring and reporting should be strengthened to promote the rational use of drugs of the clinical.