人乳头状瘤病毒16型感染与结直肠癌的相关性研究

Study on correlation between human papillomavirus 16 infection and colorectal cancer

目的分析人乳头状瘤病毒(HPV)16型感染与结直肠癌的相关性,为临床预防治疗提供理论参考依据。方法选取2013年9月-2015年9月南阳市中心医院收治的结直肠癌患者148例为结直肠癌组,同期选取医院接受肠镜检查的健康人员140名为健康对照组,收集两组受试人员的病理组织,使用免疫组化的方法检测两组人群HPV16型阳性率,数据采用SPSS 19.0软件进行统计分析。结果 148例结直肠癌组患者HPV16阳性101例,阳性率为68.24%,140名健康对照组HPV阳性15名,阳性率为10.71%,结直肠癌组HPV感染率明显高于健康对照组,经统计检验,差异有统计学意义(P<0.05)。结论结直肠癌的发生与人乳头状瘤病毒16型感染密切相关,且随着临床Dukes分期的不同,感染率有显著差异。

OBJECTIVE To investigate the correlation between human papillomavirus（HPV）16infection and colorectal cancer so as to provide theoretical basis for clinical prevention and treatment.METHODS A total of 148 patients with colorectal cancer who were treated in Nanyang Central Hospital from Sep 2013 to Sep 2015 were assigned as the colorectal cancer group,meanwhile,140 healthy people who received the colonoscopy were chosen as the control group.The pathological tissues were collected from the two groups of participants,the positive rates of HPV16 were detected by using immunohistochemical method,and the statistical analysis of data was performed with the use of SPSS 19.0software.RESULTS Of the 148 patients with colorectal cancer,101 were detected positive for HPV16,with the positive rate 68.24%.Of the 140 healthy people in the control group,15 were detected positive for HPV,with the positive rate 10.71%;the incidence rate of HPV infection of the colorectal cancer group was significantly higher than that of the control group（P0.05）.CONCLUSIONThe incidence of colorectal cancer is closely associated with the HPV16 infection,and the infection rate varies in the different clinical Dukes stages.