血清细胞因子与肝硬化腹水感染关系分析

Relationship between serum cytokines and liver cirrhosis ascites infections

目的研究血清细胞因子与肝硬化腹水感染的关系,为感染的预防和治疗提供参考依据。方法选取2013年6月-2014年12月于医院进行治疗的38例肝硬化腹水感染患者为感染组,同期的38例肝硬化腹水未发生感染患者为非感染组,38名健康人员为正常组,将3组受试人员的血清细胞因子水平进行比较,同时比较感染组和非感染组中轻度、中度和重度腹水患者的检测结果,以logistic分析上述指标与肝硬化腹水感染的关系。结果感染组患者血清细胞因子包括白介素6(IL-6)、白介素8(IL-8)、γ-干扰素(IFN-γ)及肿瘤坏死因子α(TNF-α)水平分别为(14.52±1.89)pg/ml、(16.64±1.99)pg/ml、(23.84±2.46)ng/L及(3.89±0.37)ng/ml,其均高于非感染组及正常组,非感染组则高于正常组;感染组轻度、中度、重度腹水者的检测水平均高于非感染组,经logistic分析显示,上述血清指标均与肝硬化腹水感染有密切的关系,差异有统计学意义(P<0.05)。结论肝硬化腹水感染患者的血清细胞因子呈现高表达状态,应加强对该类患者血清细胞因子的监测及干预。

OBJECTIVE To investigate the relationship between the serum cytokines and the liver cirrhosis ascites infections so as to provide guidance for prevention and treatment of the infections.METHODS Totally 38 patients with liver cirrhosis ascites infections who were treated in the hospital from Jun 2013 to Dec 2014 were assigned as the infection group,meanwhile,38 liver cirrhosis patients without ascites infections were chosen as the non-infection group,and 38 healthy people were set as the control group.The levels of serum cytokines were compared among the three groups of participants,and the levels of serum cytokines of the patients with mild,moderate,or severe ascites were compared between the infection group and the non-infection group;the logistic analysis was performed for the relationship between the above indicators and the liver cirrhosis ascites infections.RESULTS The levels of serum interleukin 6（IL-6）,interleukin 8（IL-8）,γ-interferon（IFN-γ）,and tumor necrosis factorα（TNF-α）of the infection group were respectively（14.52±1.89）pg/ml,（16.64±1.99）pg/ml,（23.84±2.46）ng/L,and（3.89±0.37）ng/ml,higher than those of the non-infection group and the control group;the levels of the serum cytokines of the non-infection group were higher than those of the control group.The levels of the serum cytokines of the patients with mild,moderate,or severe ascites were higher in the infection group than in the noninfection group.The logistic analysis indicated that the above serum indicator were closely associated with the liver cirrhosis ascites infections（P0.05）.CONCLUSIONThe serum cytokines of the patients with liver cirrhosis ascites infections show high expression state.It is necessary to strengthen the surveillance of the serum cytokines and take intervention measures.