疱疹病毒及人乳头状瘤病毒感染与鼻窦内翻性乳头状瘤的临床关系

Clinical relationship between human herpes virus and human papilloma virus infections and paranasal sinuses inverted papilloma

目的探讨鼻、鼻窦内翻性乳头状瘤患者中人疱疹病毒(EBV)、人乳头状瘤病毒(HPV)感染情况,旨在了解EBV与HPV在鼻、鼻窦内翻性乳头状瘤中的影响。方法选取医院2013年6月-2015年6月40例鼻、鼻窦内翻性乳头状瘤患者作为研究对象,采用聚合酶链反应法检测鼻、鼻窦内翻性乳头状瘤石蜡包埋组织中EBV与HPV;选择鼻、鼻窦内翻性乳头状瘤患者40例为试验组,其中10例乳头状瘤恶变,30例鼻、鼻窦内翻性乳头状瘤;且另外选择20例鼻息肉患者为对照组。结果试验组患者HPV检出阳性27例阳性率67.5%,EBV检出阳性17例检出阳性率42.5%,均明显的高于对照组的10.0%及5.0%,差异有统计学意义(P<0.05);试验组中30例鼻、鼻窦内翻性乳头状瘤患者中HPV单独感染14例,EBV单纯感染4例,HPV与EBV混合感染8例;10例乳头状瘤恶变HPV单纯感染5例,EBV单纯感染4例,HPV与EBV混合感染1例;复发与未复发患者中HPV感染率分别为64.7%、65.2%,EBV感染率分别为47.1%、8.7%,EBV感染率在复发组与未复发患者中比较差异有统计学意义(P<0.05)。结论鼻、鼻窦内翻性乳头状瘤患者存在有EBV、HPV感染,且二者病毒与鼻、鼻窦内翻性乳头状瘤的之间具有紧密的关系,临床中应引起足够的重视。

OBJECTIVE To explore the prevalence of human herpes virus（EBV）and human papilloma virus（HPV）infections in patients with nose,paranasal sinuses inverted papilloma so as to understand the role of EBV and HPV in the nose,paranasal sinuses inverted papilloma.METHODS A total of 40 patients with nose,paranasal sinuses inverted papilloma who were treated in the hospital from Jun 2013 to Jun 2015 were recruited as the study objects.The EBV and HPV in the nose,paranasal sinuses papilloma paraffin-embedded tissues were detected by using polymerase-chain-reaction assay.Totally 40 patients with nose,paranasal sinuses inverted papilloma were assigned as the experimental group,including 10 cases of papilloma malignancy and 30 cases of nose,paranasal sinuses inverted papilloma.Totally 20 patients with nasal polyps were chosen as the control group.RESULTS The HPV was tested positive in 27 cases of the experimental group,with the positive rate 67.5%;the EBV was tested positive in17 cases of the experimental group,with the positive rate 42.5%;the positive rates of HPV and EBV were significantly higher in the experimental group than in the control group（P0.05）.Of the 30 patients with nose,paranasal sinuses inverted papilloma in the experimental group,14 had single HPV infection,4had single EBV infection,and 8had mixed HPV and EBV infection.Of the 10 patients with papilloma malignancy,5had single HPV infection,4had single EBV infection,and 1had mixed HPV and EBV infection.The incidence rate of HPV infection was 64.7%in the patients with recurrence,65.2%in the patients without recurrence;the incidence rate of EBV infection was 47.1%in the patients with recurrence,8.7%in the patients without recurrence;while there was significant difference in the incidence rate of EBV infection between the patients with recurrence and the patients without recurrence（P0.05）.CONCLUSIONThe EBV and HPV infections are prevalent in the patients with nose,paranasal sinuses inverted papilloma,and the two species of viruses are closely associated with the nose,paranasal sinuses inverted papilloma,to which the hospital should pay high attention.