莫匹罗星软膏治疗皮肤感染的临床效果分析

Clinical effect of mupirocin ointment on treatment of skin infections

目的探讨莫匹罗星软膏治疗皮肤感染的临床效果,为临床选择有效药物提供依据。方法 2014年10月-2015年10月在医院收治的皮肤轻中度感染患者150例为研究对象,采取随机的方法分为观察组与对照组,每组各75例;两组患者均给予常规的抗菌药物进行治疗,在此基础上,观察组给予莫匹罗星软膏涂抹患处,每日3次,连续使用7d;观察两组患者治疗效果和病原菌清除率,采用SPSS 19.0对数据进行统计分析。结果 150例皮肤感染患者中检出金黄色葡萄球菌62株、大肠埃希菌43株、铜绿假单胞菌18株、凝固酶阴性葡萄球菌10株、溶血链球菌9株、其他8株;外科创伤55例占36.66%、蜂窝织炎46例占30.67%、动物咬伤21例占14.00%、糖尿病皮肤溃疡15例占10.00%、其他13例占8.67%;观察组患者治疗有效率为97.33%、对照组为86.67%,观察组治疗有效率明显高于对照组,差异有统计学意义(P<0.05);观察组细菌清除率为96.00%、对照组为85.33%,观察组细菌清除率明显高于对照组,差异有统计学意义(P<0.05)。结论莫匹罗星软膏治疗皮肤感染临床效果显著,细菌清除率较高。

OBJECTIVE To observe the clinical effect of mupirocin ointment on treatment of skin infections so as to provide guidance for reasonable clinical use of antibiotics.METHODS A total of 150 patients with mild and moderate skin infections who were treated in hospitals from Oct 2014 to Oct 2015 were recruited as the study objects and randomly divided into the observation group and the control group,with 75 cases in each.Both groups were treated with conventional antibiotics,the observation group was given additional mupirocin ointment for smearing of the affected area,three times a day,continuous use for 7days.The therapeutic effects and clearance rates of pathogens were observed and compared between the two groups of patients,and the statistical analysis of data was performed with the use of SPSS19.0software.RESULTS Of the pathogens isolated from the 150 patients,there were 62 strains of Staphylococcus aureus,43 strains of Escherichia coli,18 strains of Pseudomonas aeruginosa,10 strains of coagulase-negative Staphylococcus,9strains of Streptococcus hemolyticus,and 8strains of other species of pathogens.Totally 55（36.66%）patients had surgical trauma,46（30.67%）patients had cellulitis,21（14.00%）patients had animal bites,15（10.00%）patients had diabetic skin ulcers,and 13（8.67%）patients had other diseases.The effective rate of treatment of the observation group was 97.33%,significantly higher than86.67% of the control group（P0.05）.The bacterial clearance rate of the observation group was 96.00%,significantly higher than 85.33% of the control group（P0.05）.CONCLUSION The mupirocin ointment can achieve significant clinical effect on treatment of skin infections,with the bacterial clearance rate high.