宫颈上皮内瘤变与宫颈癌患者人乳头状瘤病毒感染的临床分析

Clinical analysis of cervical intraepithelial neoplasia and human papillomavirus infection in cervical cancer patients

目的宫颈上皮内瘤变及宫颈癌患者人乳头状瘤病毒(HPV)感染的临床分析,为宫颈上皮内瘤变和宫颈癌患者的临床检测以及防治提供依据。方法选取2010年1月-2015年1月128例在医院进行诊治的宫颈上皮内瘤变和宫颈癌患者进行HPV感染亚型调查,随机分为试验组与对照组,每组各64例;观察两组患者的HPV检出的临床特点。结果试验组64例患者中单一型HPV感染41例,多重型HPV感染23例;对照组64例患者中单一型HPV感染44例,多重型HPV感染20例,两组比较差异无统计学意义;在128例宫颈上皮内瘤变及宫颈癌患者中检出率较高的HPV类型有HPV16型54株、HPV58型17株、HPV33型16株、HPV52型9株、HPV18型8株、HPV31型8株;各级宫颈上皮内瘤变和宫颈癌患者中高危险HPV感染检出率较低,低危型HPV感染检出率较高。结论宫颈上皮内瘤变和宫颈癌患者中的HPV感染率较高,可以使用导流杂交技术检测方法对HPV亚型进行检测,对于临床预防宫颈上皮内瘤变以及宫颈癌等方面的疾病具有重要的意义。

OBJECTIVE To investigate the cervical intraepithelial neoplasia and human papillomavirus（HPV）infection in cervical cancer patients so as to provide guidance for clinical detection and prevention of the cervical intraepithelial neoplasia and cervical cancer.METHODS A total of 128 cervical intraepithelial neoplasia and cervical cancer patients who were treated in the hospital from Jan 2010 to Jan 2015 were enrolled in the study,then the subtypes of HPV infection were investigated,the enrolled patients were randomly divided into the experimental group and the control group,with 64 cases in each.The clinical characteristics of detection of HPV were observed and compared between the two groups of patients.RESULTS Of the 64 patients in the experimental group,41 had single type HPV infection,and 23 had multiple types of HPV infection.Of the 64 patients in the control group,44 had single type HPV infection,and 20 had multiple types of HPV infection,and there was no significant difference between the two groups.Of the subtypes of HPV that were detected positive in the 128 patients with cervical intraepithelial neoplasia and cervical cancer,54 strains were HPV16,17 strains were HPV58,16 strains were HPV33,9strains were HPV52,8strains were HPV18,and 8strains of HPV31.The detection rate of high-risk HPV infection was relatively low in the patients with cervical intraepithelial neoplasia and cervical cancer,while the detection rate of the low-risk HPV infection was relatively high.CONCLUSION The incidence rate of HPV infection is relatively high in the patients with cervical intraepithelial neoplasia and cervical cancer.The subtypes of HPV can be detected by using diversion hybridization technique,which has great significance in clinical prevention of cervical intraepithelial neoplasia and cervical cancer.