信号通路在膝骨关节炎实验研究中的进展

Experimental progress of signal transduction pathways in knee osteoarthritis

背景:研究表明信号通路在膝骨关节炎发病过程中起着重要的作用。目的:详细阐述信号通路在膝骨关节炎的实验研究进展。方法:查阅PubM ed、CNKI、维普、万方等相关数据库,查找关于膝骨关节炎的信号通路实验研究的相关文献,对资料进行筛选,排除重复研究和关联性较小的文献,保留与膝骨关节炎信号通路关联性较大的文献。结果与结论:共纳入51篇符合标准的文献,包括中文文献20篇,英文文献31篇。经分析得出:与膝关节骨性关节炎相关的信号通路主要集中在软骨细胞的增殖和软骨细胞的凋亡两个方面。与软骨细胞增殖有关的信号通路主要有Notch信号通路和Wnt信号通路;与软骨细胞凋亡的信号通路有基质细胞衍生因子1/趋化因子受体4信号通路、TLR4信号通路和MAPKs信号通路;Hippo-YAP信号通路与ERK1/2信号通路具有双重调节软骨细胞增殖和凋亡的作用。

BACKGROUND： Studies have shown that signaling pathway plays an important role in the pathogenesis of knee osteoarthritis. OBJECTIVE： To elaborate the experimental progress of signal transduction pathway in knee osteoarthritis METHODS： A computer-based retrieval of Pub Med, CNKI, VIP and Wanfang databases was performed to find the relevant literatures concerning experimental studies of signaling pathway in knee osteoarthritis. All data were primarily screened to exclude repeated and irrelevant articles. Articles about association between knee osteoarthritis and signal pathway were included.RESULTS AND CONCLUSION： A total of 51 articles were collected, including 20 in Chinese and 31 in English. It is concluded that the signal transduction pathway related to knee osteoarthritis is mainly concentrated in the two aspects： the proliferation of chondrocytes and the apoptosis of chondrocytes. The signal transduction pathways related to the proliferation of chondrocytes mainly include Notch signaling pathway and Wnt signaling pathway. SDF-1/CXCR4 signaling pathway, TLR4 signaling pathway, and MAPKs signaling pathway are associated with apoptosis in chondrocytes. Hippo-YAP signaling pathway and ERK1/2 signaling pathway have a double role in the regulation of proliferation and apoptosis of chondrocytes.