乌司他丁对重症烧伤患者血小板水平及凝血功能的影响

Effects of Ulinastatin on Platelet and Blood Coagulation Function in Severe Burn Patients

【目的】探讨乌司他丁对重症烧伤患者血小板水平及凝血功能的影响。【方法】选择本院2013年1月至2014年1月就诊的重症烧伤患者25例，将其随机分为观察组（n=13）和对照组（n=12），对照组给予常规治疗，观察组患者在常规治疗的基础上静脉注射乌司他丁，连续用药7d。观察治疗前及治疗后d1、d3、d7血小板计数（PLT）、血小板粘附率（PAR）、血小板分布宽度（PDW）及血小板平均容积（MPV）的变化，并检测两组患者治疗前及治疗后凝血酶原时间（PT）、凝血酶时间（TT）、部分凝血活酶时间（APTT）、血浆纤维蛋白原（FIB）及血浆-D二聚体（DD）水平。【结果】观察组治愈率显著高于对照组，创面脓毒症、创面感染、电解质紊乱、器官功能障碍发生率均低于对照组，差异均具有统计学意义（均P〈0．05）；与治疗前比较，两组患者治疗后d1、d3、d7血小板PLT、PAR、MPV、PDW水平显著高于治疗前，差异具有统计学意义（P〈0．05）；两组患者PT、APTT治疗后较治疗前均明显缩短，FIB、DD水平明显降低，差异均具有统计学意义（均P〈0．05）。【结论】重症烧伤患者应用乌司他丁对凝血功能具有一定的改善作用，对其病情变化、并发症、器官功能均有较好改善作用。

[ObjectivelTo observe the effects of ulinastatin on platelet and blood coagulation function in severe burn patients.[Methods] Twenty-five patients with severe burns treated in our hospital from January 2013 to January 2014 were randomly divided into experimental group （ n = 13） and control group （ n = 12） . Routine treatment were conducted for the control group, whereas the experimental group were given an injection of ulinastatin with continuous administra- tion 7 d based on the above conventional treatment scheme. Changes of platelet count （PLT）, platelet adhesion rate （PAR）, platelet distribution width （PDW） and mean platelet volume （MPV）of the experimental group were observed before and after treatment D1 D3 DT. Prothrombin time （PT）, thrombin time （TT）, activated partial thromboplastin time （APTT）, plasma fibrinogen original （FIB） and plasma - two D dimer （DD） levels of two groups of patients were meas- ured before and after treatment.[Results] The cure rate of the observation group was significantly higher than that of the control group： wound sepsis, wound infection, electrolyte disorders and organ dysfunction rate were lower than those of the control group, the differences were statistically significant （ P 〈0.05）. PT and APTT of the two groups were significantly decreased after and before treatment. FIB and DE） were significantly decreased, the difference was statistically significant （ P 〈0.05）.[Conclusion] Ulinastatin administrated on severe burn patients have a positive effect on blood coagulation function, and has a good efficacy on their illness, complications and organ function.