纤维素接枝聚甲基丙烯酸甲酯的制备及其药物缓释性能研究

Study on preparation and drug delivery properties of cellulose graft polymethyl methacrylate

利用烯类单体通过接枝共聚将纤维素功能化。在1-烯丙基-3-甲基氯代咪唑(AMIMCl)离子液体中,纤维素和简单的有机卤化物通过氧化还原反应合成了大分子引发剂纤维素2-溴丙酸酯,利用原子转移自由基聚合(ATRP)法接枝共聚合成了纤维素接枝聚甲基丙烯酸甲酯材料(cellulose-g-PMMA),从而实现活性种与休眠种之间的可逆动态平衡。并且通过核磁共振(NMR)、傅立叶变换红外光谱(FTIR)以及透射电子显微镜(TEM)等测试,对该材料进行了物理检测。利用白桦脂酸作为模型药物,并采用纳米沉淀法成功制备了纤维素/白桦脂酸纳米药物,并对其缓释性能及释放进行了探讨。结果表明:cellulose-g-PMMA具有作为缓释药物载体的潜力。

The cellulose graft polymethyl methacrylate was prepared with vinyl monomers by graft copolymerization.In the 1-allyl-chloro-3-methyl-imidazole（AmimCl）ionic liquids,cellulose 2-bromo-propionyl bromide was synthesized through cellulose and simple organic halides by a redox reaction.Using atomic transfer radical polymerization（ATRP）method,cellulose grafted poly（methyl methacrylate）material（cellulose-g-PMMA）were synthesized.A reversible dynamic equilibrium between the active species and the dormant species were achieved.The material were tested by nuclear magnetic resonance（NMR）,Fourier transform infrared spectroscopy（FTIR）,transmission electron microscopy（TEM）.Using Betulinic acid as a model drug,cellulose/betulinic acid nanodrug was successfully prepared.The sustained release properties of the nanodrug were investigated.The results showed that cellulose-g-PMMA has potential as a controlled release drug carrier.