TRIB3基因的研究进展

Progress of TRIB3 gene research

TRIB3是一个重要的应激相关基因，可被多种刺激因素诱导上调表达，参与多个信号转导通路，在细胞凋亡、血糖和脂质代谢、脂肪细胞分化、细胞应激等过程发挥着重要作用。多个研究表明 TRIB3与2型糖尿病进展密切相关，能够介导胰岛β细胞的凋亡以及胰岛素抵抗。近年研究发现，TRIB3在多种肿瘤组织中高表达，且与肿瘤的分期、复发等预后密切相关，提示 TRIB3可能是肿瘤靶向治疗的新靶点。现对TRIB3的研究进展作一综述。

Tribbles homolog 3（TRIB3,also named TRB3,NIPK,and SKIP3）belongs to the tribbles family of pseudokinases,that were first identified in Drosophila to regulate cell division and migration.TRIB3 expression is upregulated by endoplasmic reticulum stress,hypoxia,and nutrient starvation.Previous studies showed that TRIB3 expression was closely related to the progression of type 2 diabetes mellitus,and that TRIB3 mediated apoptosis in islet beta cells,as well as insulin resistance.Recent studies suggested that TRIB3 is a potential oncogene,as evidenced by its elevated expression in colorectal cancer,breast cancer,liver cancer and other cancer tissues.