人乳头瘤病毒联合薄层液基细胞检查在子宫颈疾病筛查中的应用

Application of human papillomavirus combined with thinprep cytology test in screening of cervical diseases

目的：探讨人乳头瘤病毒（HPV）联合薄层液基细胞检查（TCT）在子宫颈疾病筛查中的应用价值。方法选择2014年1月至12月在山西省肿瘤医院妇科就诊的患者，同时行HPV、TCT检查，异常者行病理活组织检查，获得病理学结果者276例。比较HPV、TCT及HPV联合TCT检测的敏感度、与病理检查的符合率等指标，评价诊断价值。结果276例患者中，HPV阳性225例（81.52%），主要为HPV16型和HPV18型，与病理阳性符合率为79.56%（179／225）；TCT阳性242例（87.68%），与病理阳性符合率为76.86%（186／242）；HPV与TCT二者联合检测与病理阳性符合率为94.71%（197／208），高于单项检测（P＜0.01）。结论 HPV检测联合TCT可降低漏检率，提高子宫颈癌筛查的准确性，在子宫颈癌筛查中具有重要的应用价值。

Objective To investigate the application value of human papillomavirus （HPV） combined with thinprep cytology test （TCT） detection in screening of cervical cancer. Methods 276 patients were enrolled to have HPV and TCT tests at Department of Gynecology, Shanxi Cancer Hospital from January to December in 2014. Pathological examine was applied to the patients with abnormal results of HPV and TCT. The diagnostic value of HPV, TCT and their combinations was evaluated by the diagnostic sensitivity and the rate of coincidence with the pathological examine results. Results The sensitivity of HPV and its coincidence with the pathological examine results were 81.52 % （225/276） and 79.56 % （179/225）, respectively, while those of TCT were 87.68%（242/276） and 76.86%（186/242）, respectively. The coincidence rate between the combination method and the pathological examination was higher （94.71%, 197/208） than the individual test. Conclusion HPV combined with TCT detection can reduce the misdiagnosis rate and improve the diagnostic accuracy rate, indicating that this method is of great value in the cervical cancer screening.