非受体酪氨酸激酶-信号转导和转录激活因子信号通路作为结肠癌治疗新靶点的研究进展

Research progress of non-receptor tyrosine kinase signal transducer and activator of transcription as a new target in colon cancer

癌变的结肠细胞增殖、侵袭和转移时依赖血管生成及有利的肿瘤微环境。非受体酪氨酸激酶-信号转导和转录激活因子（JAK-STAT）信号通路参与慢性炎症相关的肿瘤发生、癌细胞增殖、肿瘤血管生成、免疫逃逸、肿瘤转移多个过程，因此有望成为分子靶向治疗的新靶点。现对JAK-STAT信号通路在结肠癌发生、发展中的研究进展进行综述，并初步探讨JAK-STAT在靶向治疗及预后评估方面的应用前景。

Malignant colon cells require angiogenesis and optimal tumor microenvironment for proliferation, invasion and metastasis. The non-receptor tyrosine kinase signal transducer and activator of transcription （JAK-STAT） pathway are involved in multiple processes, including chronic inflammation-associated tumorigenesis, cancer proliferation, tumor angiogenesis, immune evasion and facilitating tumor metastasis, making JAK-STAT a new target in molecular target therapy. In this review, advances on JAK-STAT pathway as a new target in colon tumorigenesis are updated, and a preliminary estimation of JAK-STAT in prognosis and target therapy will be mentioned to show a potential future of JAK-STAT in colon cancer.