1008个冷冻胚胎移植周期妊娠结局影响因素的分析

Factors affecting the outcome of 1008 frozen- thawed embryo transfer cycles

目的:探讨影响卵裂期冷冻胚胎移植妊娠结局的相关因素。方法:回顾性分析2011年1月至2014年12月在北京大学第一医院进行卵裂期冻胚移植的1008个周期,探讨患者年龄、不孕年限、不孕类型、内膜准备方式、内膜厚度及类型、受精方式、胚胎冷冻方法、辅助孵化、胚龄、移植胚胎数量及质量等对冷冻胚胎移植妊娠结局的影响。结果:1008个胚胎解冻周期,复苏胚胎2883个,存活2503个(86.8%),完成冻胚移植周期981个(97.3%),临床妊娠周期413个(42.9%),胚胎种植率23.6%,早期流产率14.0%。年轻患者、全胚冷冻后第一次冻胚移植、选择玻璃化冷冻方法、移植≥2枚胚胎尤其是≥2枚优质胚胎的冷冻胚胎移植妊娠率较高。结论:在诸多因素中,年龄、冷冻方法、是否全胚胎冷冻、移植胚胎数目及质量对冻胚移植妊娠结局影响显著。

Objectives： To determine the impact of the clinical and embryological factors on the pregnancy outcome of frozen- thawed embryo transfer. Methods： The data of 1008 cleavage stage frozen- thawed embryo transfer cycles were assessed at Peking University First Hospital from January 2011 to December 2014. Results：2883 frozen embryos included in 10083 cycles were thawed with a survival rate of 86. 8%. Embryos were transferred for 981 cycles; the overall clinical pregnancy rate per embryo transfer cycle was 42. 9%; the embryo implanted rate and early abortion rate were 23. 6% and 14. 0%,respectively. The clinical pregnancy rate was higher in women who were younger than 40 years,who were in first frozen- thawed embryo transfer cycles after overall embryo frozen in fresh cycles,whose embryos cryopreservation used vitrification method,whose number of transferred embryos,and high- quality thawed embryos transferred was ≥2. Conclusions： The female＇s age,whether is the first frozen- thawed embryo transfer cycles after overall embryo frozen in fresh cycles,embryos cryopreservation method,the number of transferred embryos and high- quality thawed embryos transferred are the factors affecting pregnancy outcome of frozen- thawed embryo transfer.