摘要
目的制备蛇床子素脂质体凝胶剂,并对其体外渗透量及皮肤贮库效应进行考察。方法采用薄膜分散法制备蛇床子素脂质体,再以卡波姆-940为基质制备脂质体凝胶剂;采用Franz扩散池法进行体外透皮试验,以高效液相色谱法测定蛇床子素的累积渗透量,通过药物的透皮给药吸收来评价蛇床子素脂质体凝胶剂的性能。结果蛇床子素脂质体凝胶剂的渗透行为符合Higuchi方程,其中24 h的皮肤累积渗透量达到172.95μg/cm^2,贮库后的皮肤累积渗透量达到210.19μg/cm^2。结论蛇床子素脂质体凝胶剂可透过皮肤被吸收,具有长效缓释作用,为研制蛇床子素的新型透皮制剂奠定了基础。
Objective To prepare the osthole liposome gel and evaluate the skin storage effect and the cumulative penetration in vitro. Methods The osthole liposomes were prepared by using the thin film dispersion method,and the Carbopol-940 was added as matrix for the preparation of the osthole liposome gel. In vitro transdermal experiments were done by Franz diffusion pool method. The cumulative release of osthole was determined by HPLC method to evaluate the drug absorption performance of osthole liposome gel. Results The absorption curve of osthole liposome gel was consistent with Higuchi function. The cumulative penetration of osthole liposome gel in 24 hours was 172. 95 μg / cm2 in vitro transdermal experiments,while the cumulative penetration was 210. 19 μg / cm2 in skin library storage experiments.Conclusion Osthole liposome gel can be absorbed through the skin with long-acting slow-release effect,and this experiment can provide a reference for the development of osthole transdermal preparations.
出处
《广东药学院学报》
CAS
2016年第1期5-8,共4页
Academic Journal of Guangdong College of Pharmacy