小气道指标对支气管激发试验结果的预测价值

PREDICTIVE VALUE OF SMALL AIRWAY INDICATIOR FOR THE RESULTS OF BRONCHIAL PROVOCATION TEST

目的:探讨慢性咳嗽患者小气道功能指标对支气管激发试验(BPT)结果的预测价值。方法:160例慢性咳嗽患者行支气管激发试验,分别比较阳性和阴性患者的小气道功能,并评价其与支气管激发试验结果的相关性。结果:与阴性组比较,支气管激发试验阳性组患者25%、50%、75%肺活量位的用力呼气流速(FEF 25%、FEF 50%、FEF 75%)和最大呼气中期流速(MMEF 75/25)明显降低(P<0.05)。慢性咳嗽患者FEF 50%和MMEF 75/25与激发试验后第1秒用力呼气量(FEV1)的下降率呈负相关(P<0.05)。FEF 75%、FEF 50%、FEF25%、MMEF 75/25对支气管激发试验的阳性结果有一定的预测价值。结论:FEF 50、MMEF 75/25可用来预测支气管激发试验后FEV1的下降率;基础小气道功能对支气管激发试验的结果有一定的预测价值。

Objective： To investigate the predictive value of small airway indicators for the results of bronchial provocation test （BPT） in patients with chronic cough. Methods： 160 chronic cough patients were all performed BPT and the small airway fimction of positive and negative patients were compared; as well as the relationships between small airway indicators and BPT results were analyzed. Results： Compared with negative patients, the FEF 25%, FEF 50%, FEF75% and MMEF 75/25 of BPT positive patients decreased obviously （P〈 0.05）. FEF 50% and MMEF 75/25 of chronic cough patients were negatively related to declining rote of FEV1 after BPT （P〈 0.05）. FEF 75%, FEF 50%, FEF 25% and MMEF 75/25 lind certain predictive value on BPT results. Conclusions： FEF 50% and MMEF 75/25 can predict the declining rate of FEV1 after BPT; Basic small airway functions have certain predictive value on BPT results.