脑梗死患者血清胱抑素C水平与颈动脉粥样硬化斑块的相关性

CORRELATIONS BETWEEN SERUM CYSTATIN C LEVEL AND CAROTID ATHEROSCLEROSTIC PLAQUE OF CEREBRAL INFARCTION PATIENTS

目的:探讨脑梗死患者血清胱抑素C(Cys-C)水平与颈动脉粥样硬化斑块的关系。方法:181例急性脑梗死患者依据有无颈动脉斑块分为颈动脉正常组53例和颈动脉斑块组128例,检测两组患者Cys-C、同型半胱氨酸、高敏感C反应蛋白(hs-CRP)、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白和单核细胞绝对值(MONO)。结果:与颈动脉正常组比较,颈动脉斑块组患者年龄、男性患者比例,血清Cys-C、hs-CRP、MONO明显升高(P<0.05)。Logistic回归分析显示,性别、血清Cys-C水平是颈动脉粥样硬化斑块形成的独立危险因素(P<0.05)。结论:血清Cys-C水平是颈动脉粥样硬化斑块形成的独立危险因素。

Objective： To investigate the relationships between serum cystatin C （Cys-C） level and carotid atherosclerosis plaque of cerebral infarction patients. Methods： 181 cases cerebral infarction patients were divided into normal group （n=53） and carotid atherosclerosis plaque group （n=128）. The Cys-C, homocysteine, high sensitive c-reactive protein （hs-CRP）, total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein and MONO in serum of patients in 2 groups were respectively detected Results： Compared with normal group, the age, proportion of male patients, Cys-C, hs-CRP and MONO level in serum ofpatients in carotid atherosclerosis plaque group increased obviously （P〈0.05）. Logistic regression analysis showed that gender and serum Cys-C level were independent risk factors for formation of carotid atherosclerotic plaques. Conclusions： Serum Cys-C level is an independent risk factor for formation of carotid atherosclemtic plaques.