摘要
目的:探讨丙戊酸钠及氯硝西泮治疗迟发性运动障碍(tardive dyskinesia,TD)的疗效和不良反应。方法:将123例迟发性运动障碍患者按随机数字表法分为观察组和对照组,观察组患者给予丙戊酸钠和氯硝西泮,对照组患者给予安慰剂维生素B_6。通过异常不自主运动量表(AIMS)评分对患者治疗前,治疗第2、4、8周末的效果进行评定,观察患者的疗效及不良反应。结果:观察组患者应用丙戊酸钠和氯硝西泮治疗后,第2、4、8周末AIMS评分较治疗前明显下降,且明显优于对照组,差异均有统计学意义(P<0.05);观察组患者TD部位的有效率均达到90.00%以上,而对照组患者有效率均低于10.00%,差异均有统计学意义(P<0.05);2组患者均未见明显不良反应。结论:丙戊酸钠及氯硝西泮治疗TD安全有效,值得临床推广。
OBJECTIVE： To probe into the efficacy and adverse reactions of sodium valproate and clonazepam in treatment of tardive dyskinesia（TD）.METHODS： 123 cases with TD were divided into observation group and control group via the random number table.The observation group were treated with sodium valproate and clonazepam,the control group received placebo vitamin B_6.The effects of before and after 2,4,8 weeks were determined via abnormal involuntary movement scale（ AIMS）.The efficacy and adverse reactions in patients were observed.RESULTS： After treatment with sodium valproate and clonazepam,scores of AIMS after 2,4,8 weeks were significantly decreased than before in observation group,which was better than the control group,with statistically significant difference（ P〈0.05）.The effective rate of TDwas 90.00% in observation group,while in control group,it was lower than 10.00%,with statistically significant difference（ P〈0.05）.There was no obvious adverse reactions between two group pf patients.CONCLUSIONS： Sodium valproate and clonazepam in treatment of TD is safe and effective,it is worthy of clinical promotion.
出处
《中国医院用药评价与分析》
2016年第2期159-161,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
