稳心汤治疗血瘀痰阻型不稳定性心绞痛疗效观察

Observation on the Clinical Effect of Wenxin Decoction in the Treatment of Unstable Angina Pectoris of Stagnation of Blood and Phlegm Type

目的观察自拟稳心汤治疗血瘀痰阻型不稳定性心绞痛的临床疗效。方法 2组患者均给予卧床休息,心电监护,对照组予调脂、抗血小板、B阻剂及ACEI制剂等药物常规治疗。治疗组:在对照组的基础上加服自拟稳心汤。2组患者均在心绞痛发作时服用硝酸甘油。2组均住院治疗7d,病情稳定后出院。结果治疗组与对照组心绞痛总有效率分别为81.82%和63.64%,中医症候总有效率分别为86.36%和54.55%,心电图总有效率分别为81.82%和68.18%,2组比较均有显著性差异(P<0.05);治疗组治疗后超敏C反应蛋白降低(P<0.05),与对照组相比存在显著性差异(P<0.05)。结论自拟稳心汤治疗血瘀痰阻型不稳定性心绞痛在改善心绞痛症状、中医症候、缺血心电图、超敏CRP等方面可能有一定的疗效。

Objective To observe the clinical therapeutic effect of Wenxin decoction in treating unstable angina pectoris. Methods 44 patients of stagnation of blood and phlegm type suffered from unstable angina pectoris were randomly divided into two groups. All pa-tients of the two groups were treated with bed rest and ECG monitoring. 22 patients in the control group were treated with Aspirin,Simvastatin, Metoprolol and ACEI drugs. Another 22 patients in the treatment group were treated with Wenxin decoction on the basis of the control group. Each group was observed for 7 days. Results The total effective rate in ameliorating syndrome of TCM was 86.36%and 54.55%, respectively. While in relieving angina, the total effective rate of the treatment group and the control group was 81.82 %and 63.64%, respectively, and in improving ECG changes was 81.82% and 63.64%, respectively. The difference of the two parameters between the two groups was significant（P0.01）. After treatment, in the treatment group, the levels of high-sensitivity C-reactive protein were lowered obviously（P0.05）, which were more effective than those in the control group（P0.05）. Concolusion Wenxin decoction may have some effect in treating the patient（of stagnation of blood and phlegm type） suffered from unstable angina pectoris in amelio-rating symptom of angina and syndrome of TCM, ischemic changes in ECG as well as lowering high-sensitivity C-reactive level.