高效液相色谱法测定覆铜板粘结片中的N,N-二甲基乙酰胺残余量

Determination of Dimethylacetamide Content in Copper Clad Laminate Prepreg by High Performance Liquid Chromatography

建立高效液相色谱法检测覆铜板粘结片中N,N- 二甲基乙酰胺残余量的方法.以甲醇溶液萃取覆铜板粘结片中的N,N- 二甲基乙酰胺,高效液相色谱法测定N,N- 二甲基乙酰胺的含量.试验并确定了最佳色谱条件.在选定条件下,N,N- 二甲基乙酰胺含量在0.05～300 mg/L 范围内与其色谱峰面积呈良好的线性关系,线性相关系数为0.999 95,检出限为0.6 mg/kg,加标回收率为101.0%～107.8%,测定结果的相对标准偏差小于10%（n=6）.该方法准确、快速,可用于覆铜板生产的质量控制.

A method for determination of dimethylacetamide content in copper clad laminate prepreg was established by high performance liquid chromatograph (HPLC). Dimethylacetamide in copper clad laminate prepreg was extracted by methanol solution and then determined by HPLC with diode array detector. The separation conditions were studied, and the optimum conditions were selected. The content of dimethylacetamide had good linear relationship with its chromatographic peak area in the range of 0.05–300 mg/L, the liner coefficients were 0.999 95,and the detection limits were 0.6mg/kg. The recoveries ranged from 101.0%–107.8%,and the relative standard deviations of determination results were less than 10%(n=6). The method is quick and accurate, it can be used for quality control of copper clad laminate.