4′,3,4-三甲氧基-3′-香叶基或异戊烯基-2′-羟基查尔酮全合成研究

A Study of Synthesis 4,3,4-Trimethoxy-3-Pentenyl or Geranyl-2-Hydroxy Chalcone

该文以2,4-二羟基苯乙酮和3,4-二羟基苯甲醛为原料,经C-香叶基化或C-异戊烯基化、硫酸二甲酯保护、羟醛缩合得到最终产物。合成的关键是将香叶基或异戊烯基选择性引入2,4-二羟基苯乙酮的3位。所有化合物的结构都经过1 H-NMR,13 C-NMR,IR,MS分析标准。

The final products were accomplished from 2,4-dihydroxy acetophenone and 3,4-dihydroxy benzaldehyde,by C-geranylation or C-prenylation,methylation,condensation and cyclization.The key step was pentenyl or geranyl selective introduced into 2,4-dihydroxyacetophenone.All structures of compounds were confirmed by 1 H NMR,13 C NMR,IR and MS.