广西北部湾地区人群非缺失型α地贫等位基因携带者血液学数据分析

The hematology analysis on the people carrying non-deletion α thalassemia alleles in Guangxi Beibu Gulf area

目的了解广西北部湾地区人群非缺失型α地贫等位基因携带者血液学数据变化情况。方法采用Gap-PCR、PCR-RDB法对799例受测者进行分析,并对受测者MCV、MCH和Hb值进行测定。结果αQSα等位基因对携带者血液学数据影响最重,αCSα等位基因对携带者血液学数据影响与αQSα类似,αWestmeadα的影响最轻。非缺失型α地贫等位基因与--SEA或--THAI等位基因杂合,均可引发Hb H病。结论αTα等位基因携带者的MCV值或者MCH值整体比野生型个体低,因此在日常筛查活动中,我们应密切留意受检者的MCV值和MCH值,以提示疑似携带者做进一步基因检测。

Objective：To study the situation of the hematology condition of the people carrying non-deletion α thalassemia alleles in Guangxi Beibu Gulf area. Methods：The Gap-PCR and PCR-RDB were used for analysis. A total of 799 individuals were performed analysis and their hematology data of the MCV,the MCH and the Hb were recorded. Results：The hematology data changed most when the individual carrying α^QS allele,the similar condition appear in the individual carrying α^CS allele,the change is not significantly when the individual carrying α^Wstmeadα allele. When the α^T allele combined with the--^SEA or--^THAIallele,it will lead Hb H dicease. Conclusion：When the individual carrying α^T allele,his/her MCV and MCH value is lower than the wild-type individual. During the daily thalassemia screening work,we must pay attention on the MCV and the MCH value to find the suspected carriers.