复方甘草酸苷对带状疱疹后遗神经痛治疗效果的临床观察

Clinical observation of the effect of glycyrrhizin compound on postherpetic neuralgia

目的观察复方甘草酸苷治疗带状疱疹后遗神经痛的疗效。方法试验组给予阿昔洛韦600 mg口服,4次/d,复方甘草酸苷胶囊4粒,3次/d;对照组阿昔洛韦600 mg口服,4次/d;两组均给予甲钴胺片0.5 mg,3次/d,口服,酞丁胺擦剂外用,连续治疗10 d,如有疼痛,予呋喃硫胺片50 mg,3次/d,口服,停用阿昔洛韦3个月后判定疗效。结果试验组48例,治愈36例,治愈率为75.0%,总有效率为100%;对照组32例,治愈20例,治愈率为62.5%,总有效率为96.9%。试验组治愈率和总有效率均显著高于对照组(P<0.01)。结论治疗早期应用复方甘草酸苷可有效减少带状疱疹后遗神经痛的发生,有效减轻后遗神经痛的疼痛程度。

Objective To observe the effect of glycyrrhizin compound on post-herpetic neuralgia. Methods The study group was given glycyrrhizin compound capsule, 4 capsules per time, three times a day, while the control group was given acyclovir tablet 600 mg four times a day, mecobalamine tablet 0.5 mg three times a day, and topical ftiloxazone liniment. Fusultiamine tablet was applied when neuralgia happened. A 3-month follow-up was carried out. Results The cure rate of the study group was 75.0%, and the total effective rate was 100%. The cure rate of the control group was 62.5%,and total effective rate was 96.9%. The cure rate and effective rate of the study group were significantly higher than those of the control group（P 0.05）. Conclusion Early application of glycyrrhizin compound may effectively reduce the occurrence of postherpetic neuralgia.