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温阳活血利水方对慢性心衰患者利钠肽前体及生活质量影响的临床研究 被引量:5

Clinical Research on the Effect of Wenyanghuoxuelishui Decoction on NT-pro BNP and the Quality of Life in Patients with Chronic Heart Failure
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摘要 目的:观察温阳活血利水方对慢性心力衰竭的临床疗效。方法:将60例慢性心力衰竭患者随机分为治疗组与对照组,每组30例,两组均应用慢性收缩性心力衰竭的标准治疗方案,治疗组在此基础上加服温阳活血利水方,观察时间为2周。比较两组症状体征量化积分、生活质量评分、临床疗效、左心室射血分数、6 min步行试验、血浆N-末端B型利钠肽前体。结果:两组治疗前后症状体征量化积分、生活质量评分比较均有明显改善,差异有统计学意义(P<0.05)。治疗后治疗组症状体征量化积分、生活质量评分均低于对照组,差异有统计学意义(P<0.05)。治疗组总有效率为66.7%,对照组总有效率为46.7%,差异有统计学意义(P<0.05)。两组治疗前后左心室射血分数、6 min步行试验、血浆N-末端B型利钠肽前体均有明显改善,差异有统计学意义(P<0.01)。治疗后治疗组左心室射血分数、6 min步行试验、血浆N-末端B型利钠肽前体均优于对照组,差异有统计学意义(P<0.05)。治疗期间两组均无不良反应发生。结论:温阳活血利水方治疗慢性心力衰竭安全有效。 Objective: To observe the clinical effect of Wenyanghuoxuelishui decoction treatment of chronic heart failure. Methods:60 Patients with chronic heart failure were randomly divided into treatment group and control group, 30 cases for each group. Both groups treated with the standard treatment of chronic heart failure. The treatment group was treated with Wenyanghuoxuelishui decoction at the same time. Observation time was 2 weeks. The changes of signs and symptoms, quality of life(QOL) score, plasma N-terminal pro B-type natriuretic peptide(NT-pro BNP), left ventricular ejection fraction(LVEF), the 6-minute walk test(6-MWT) and comprehensive efficacy were compared between two groups. Result: There were significant differences in scores of symptoms and scores of QOL between the two groups before and after treatment(P0.05). The scores of signs and symptoms, scores of QOL in two groups had significantly improved after treatment(P0.05). Comparison between two groups after treatment, the treatment group was better than the control group(P0.01). The total effective rate of the NYHA heart function classification of the treatment group was 66.7%, and the control group was46.7%, the treatment group was better than the control group(P0.05). LVEF, 6-MWT and NT-pro BNP of two groups had significantly improved after treatment(P0.01), and the difference between the two groups was statistically significant(P0.05)。There were no adverse events during treatment in two groups. Conclusion: Wenyanghuoxuelishui decoction is safe and effective to treat chronic heart failure patients.
出处 《实用中西医结合临床》 2015年第11期7-9,共3页 Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine
基金 江苏省中医药管理局专项基金(编号:LZ13171)
关键词 慢性收缩性心力衰竭 温阳活血利水方 利钠肽前体 疗效 Chronic heart failure Wenyanghuoxuelishui decoction NT-pro BNP Effective rate
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