妊娠高血压患者血清瘦素、CysC及β-HCG水平检测的临床意义

Clinical Significance of Detection of Leptin, Cys C and β-HCG Levels in Serum of Patients with Pregnancy-Induced Hypertension

目的:研究妊娠高血压患者血清瘦素、胱抑素C(Cys C)以及人绒毛膜促性腺激素(β-HCG)水平检测的临床意义。方法:选取2014年4月到2015年4月我院收治的妊娠高血压患者90例(妊娠高血压组),另选同期正常妊娠者90例(正常妊娠组),健康体检非妊娠妇女90例(对照组),测量三组血清瘦素、Cys C以及β-HCG水平,并分析各指标的相关性。结果:妊娠高血压组和正常妊娠组血清瘦素、Cys C以及β-HCG水平均显著高于对照组,比较差异具有统计学意义(P<0.05),妊娠高血压组血清瘦素、Cys C以及β-HCG水平均显著高于正常妊娠组,比较差异具有统计学意义(P<0.05);妊娠高血压越严重血清瘦素、Cys C以及β-HCG水平越高;妊娠高血压患者血清瘦素与Cys C和β-HCG均呈正相关关系(P<0.05),Cys C与β-HCG也呈正相关关系(P<0.05)。结论:检测血清中瘦素、Cys C和β-HCG水平有利于妊娠高血压的诊断,体检时发现上述物质异常升高要高度重视。

Objective： To study the clinical significance of detection of leptin, Cystatin C（CysC） and human chorionic gonadotropin（β-HCG） levels in the serum of patients with pregnancy-induced hypertension. Methods： A total of 90 patients with pregnancy-induced hypertension, who were admitted to Shiyan Maternal and Child Health-Care Hospital of Hubei Province from April 2014 to April 2015,were chosen as pregnancy-induced hypertension group, 90 women with normal pregnancy in the same period, normal pregnancy group,90 healthy non-pregnant women, control group. Leptin, CysC and β-HCG levels of the three groups were detected, and the correlation among the indexes were analyzed. Results： Leptin, CysC and β-HCG levels in the pregnancy-induced hypertension group and normal pregnancy group were significantly higher than those in the control group, the differences were statistically significant（P〈0.05）; leptin,CysC and β-HCG levels in the pregnancy-induced hypertension group were significantly higher than those in the normal pregnancy, the differences were statistically significant（P〈0.05）. The more serious pregnancy-induced hypertension was, the higher the levels of serum leptin, CysC and-HCG were; Leptin and CysC, β-HCG of pregnancy-induced hypertension patients had a positive correlation（P〈0.05）;CysC and β-HCG also showed a positive correlation（P〈0.05）. Conclusion： Detecting serum leptin, CysC and β-HCG levels is in favour of the diagnosis of patients with pregnancy-induced hypertension.