Nestin和SOX2在皮肤恶性黑色素瘤中的表达及临床意义

Expression and Clinical Significance of Nestin and SOX2 in Cutaneous Malignant Melanoma

目的:研究巢蛋白(Nestin)和SOX2在皮肤恶性黑色素瘤中的表达及临床意义。方法:选取2010年1月-2013年1月我院收治的恶性黑色素瘤21例患者(研究组),另选黑色素痣患者21例(对照组),应用免疫组织化学法检测Nestin和SOX2,并比较两组Nestin和SOX2表达,分析其与患者生存期和转移的关系。结果:研究组Nestin和SOX2阳性表达率显著高于对照组,两组比较差异具有统计学意义(P<0.05);Nestin、SOX2阳性的恶性黑色素瘤患者生存期显著低于Nestin、SOX2阴性恶性黑色素瘤患者,两组比较差异有统计学意义(P<0.05),Nestin、SOX2阳性的恶性黑色素瘤患者与Nestin、SOX2阴性的恶性黑色素瘤患者转移率比较无统计学意义(P>0.05)。结论:Nestin和SOX2表达阳性与恶性黑色素有关,且与恶性黑色素瘤的生存期有关。。

Objective：To study the expression of nestin（Nestin） and SOX2 in cutaneous malignant melanoma and their clinical significance.Methods：A total of 21 cases of melanoma,admitted to Shiyan Taihe Hospital of Hubei Province from January 2010 to January 2013,were chosen as study group;21 cases of melanocytic nevi,as control group,Nestin and SOX2 were detected by immunohistochemical method,and the expression of Nestin and SOX2 in the two groups were compared,and the relationship between survival and transfer of patients and Nestin and SOX2 was analyzed.Results：The positive expression rates of Nestin and SOX2 in the study group were significantly higher than those in the control group,the difference was statistically significant（P0.05）.The lifetime of Nestin and SOX2-positive patients with malignant melanoma was significantly lower than that of the Nestin and SOX2-negative,the difference was statistically significant（P0.05）.There was no significant difference in the transfer rate between the Nestin and SOX2-positive patients with malignant melanoma and the Nestin and SOX2-negative（P0.05）.Conclusion：The positive expressions of Nestin and SOX2 were associated with malignant melanoma and the survival of malignant melanoma.