首发缺血性脑卒中患者血清Hcy和EPO水平的变化及临床意义

Starting in Ischemic Stroke Patients' Serum Hcy and EPO Levels of Change and Clinical Significance

目的:探究首发缺血性脑卒中患者血清同型半胱氨酸(Hcy)和红细胞生成素(EPO)水平的变化和意义。方法:于2013年10月-2015年4月我科收治的首发缺血性脑卒中患者中随机选取98例作为观察组,另选取同期健康体检者98例作为对照组,检测患者的血小板、血浆纤维蛋白原(Fib)以及血白细胞水平,比较两组血清Hcy、EPO、血小板、Fib及血白细胞水平,使用Logistic回归分析法评价缺血性脑卒中病发的危险因素,采用Spearman法对血清Hcy与EPO间相关性进行分析。结果:观察组的Hcy(23.52±12.15)m IU/L与EPO(34.61±11.25)m IU/L水平显著高于对照组的(10.57±2.18)m IU/L、(17.54±5.83)m IU/L;观察组血小板、血浆纤维蛋白原(fibrinogen,Fib)及血白细胞水平均高于对照组;差异均有统计学意义(均P<0.05)。经Logistic回归分析法分析可知,Hcy为缺血性脑卒中病发的独立因素,经Spearman相关性分析显示,首发缺血性脑卒中患者EPO水平与Hcy呈正相关。结论:缺血性脑卒中病发与血清Hcy和EPO水平升高密切相关,且Hcy是导致缺血性脑卒中病发的高危因素。

Objective：To explore the starting of ischemic cerebral apoplexy patients＇ serum Hcy and EPO level changes and meaning.Methods：From October 2013-April 2015 of 98 cases of starting in ischemic stroke patients were admitted in our department were randomly selected as observation group.Selected the same period of health physical examination 98 cases was as control group,detected the patients＇ platelets,plasma fibrinogen（Fib） and blood WBC level,compared two groups of serum Hcy,EPO,blood platelets,Fib and WBC level,used Logistic regression analysis method to evaluate the risk factors of ischemic cerebral apoplexy disease,Spearman method was used to analyze the correlation between serum Hcy and EPO.Results：The observation group＇s Hcy（23.52±12.15） m IU/L with EPO（34.61±11.25） m IU/L were significantly higher than that of control group of（10.57 ±2.18） m IU/L,（17.54±5.83） m IU/L.Observation group＇s blood platelet,Fib and white blood cell levels were higher than the control group;whcih were statistically significant differences（all P0.05）.Analysis by Logistic regression analysis method,the results showed that the Hcy was the independent factors of ischemic cerebral apoplexy disease.With Spearman correlation analysis showed that EPO starting in ischemic stroke patients with Hcy levels were positively correlated.Conclusion：The ischemic cerebral apoplexy disease are closely associated with elevated serum Hcy and EPO levels,and Hcy is lead to the risk factors of ischemic cerebral apoplexy disease.