摘要
非编码RNA包括miRNA、lncRNA、circRNA、snoRNA等,其广泛存在于真核生物细胞内,能够调控基因表达,并参与多种营养物质合成、分解的代谢过程。此外,其表达具有组织特异性,且在真核生物细胞内及循环系统中高度稳定存在,是许多慢性疾病的良好分子标志物。代谢综合征(metabolic syndrome,MS)是以肥胖为基础的多种危险因素的聚集,与激素分泌合成以及营养物质的代谢息息相关,因而会伴随糖尿病、动脉粥样硬化、心脑血管疾病等的发生。寻找MS类疾病的新的分子标志物对其早期诊断是非常必要的,而研究非编码RNA与MS的关系也可进一步阐明MS的发病机制,并为其预防和治疗提供新的方向。
Non-coding RNAs including mi RNA, lnc RNA, circ RNA, sno RNA, etc, which are widely exist in eukaryotic cells, regulate gene expression, participate in the synthesis and the metabolic process of many kinds of nutrients. In addition, its expression has tissue specificity and very stable in the circulation system, so the noon-coding RNA could serve as a biomarker for many chronic diseases. Metabolic syndrome（MS） is a cluster of metabolic risk factors including insulin resistance, hypertension（high blood pressure）, cholesterol abnormalities, and blood clotting. Affected individuals are most often overweight or obese. Metabolic syndrome is considered to be a risk factor for cardiovascular diseases and type 2 diabetes that arises due to insulin resistance and the abnormal function and pattern of body fat. Earlier diagnosis is needed to stop this global time bomb, and the relationship between non-coding RNA and MS needs to be further elucidated to provide a new way for the prevention and treatment of MS.
出处
《中华临床实验室管理电子杂志》
2015年第3期153-159,共7页
Chinese Journal of Clinical Laboratory Management(Electronic Edition）
基金
国家自然科学基金青年基金资助项目(81502587)
