Bmi-1蛋白在乳腺癌中的表达及其与临床病理学行为的相关性

Correlation between Bmi-1 protein expression and clinicopathological behaviors of breast cancer

[目的]探讨Bmi-1蛋白在乳腺癌中的表达及其与临床病理学行为的相关性.[方法]选取62例乳腺癌和62例癌旁组织芯片,利用免疫组织化学方法检测Bmi-1蛋白在乳腺癌及癌旁组织中的表达水平.[结果]Bmi-1蛋白在62例乳腺癌中的阳性表达率为83.4%,与在癌旁组织中的12.9%相比较明显升高（P〈0.01）.在TNM分期中,T2和T3,T4期阳性表达率分别为87.1%和92.0%,与T1期33.3%相比较均明显提高（P〈0.01）.有淋巴结转移的乳腺癌中阳性表达率为92.2%,与无淋巴结转移的45.5%相比较差异有统计学意义（P〈0.01）.在临床分期1~2期和3~4期中阳性表达率分别为70.8%和92.1%,相比较差异有统计学意义（P〈0.05）.[结论]Bmi-1蛋白的高表达在乳腺癌的发生、发展过程中起重要作用,且与乳腺癌的T分期、临床分期和淋巴结转移相关.

OBJECTIVETo study the correlation between Bmi-1 protein expression and clinicopathological behaviors of breast cancer.METHODS62 pairs of breast cancers and pericarcinomatous tissue microarray were sellected,and then Bmi-1 protein expression were detected by using immunohistochemistry.RESULTSThe positive rate of Bmi-1 protein expression was significantly higher in breast cancers（83.4%）than in pericarcinomatous tissues（12.9%,P〈0.01）.In TNM stage,the positive rate of Bmi-1 protein expression was significantly higher in T2（87.1%）and T3,T4（92.0%）stages than in T1（33.3%,P〈0.01）stage.In addition,the positive rate of Bmi-1 protein expression in breast cancers with lymphnode metastasis（92.2%）was significantly higher than that in breast cancers without lymphnode metastasis（45.5%,P〈0.01）.In clinical stage,the positive rate of stage 1-2and stage 3-4 was 70.8% and92.1%,respectively,and there were significant differences between the two groups（P〈0.05）.CONCLUSIONBmi-1protein over expression played important role in breast cancer development and progression,and significantly related to T stage,clinical stage and lympnode metastasis.