控释地诺前列酮对于过期妊娠引产患者的疗效

Effectiveness of controlled-release dinoprostone on odinopoeia in prolonged pregnancy

目的探讨控释地诺前列酮在过期妊娠引产中的效果。方法选取2012年1月~2014年11月平湖市第一人民医院妇产科收治的94例过期妊娠产妇随机分为2组,每组47例,对照组给予米索前列醇引产,观察组给予控释地诺前列酮引产,比较2组Bishop评分、引产效果及不良反应发生情况,观察组引产成功组与失败组蜕膜组织中前列腺素E2（prostaglandin E2,PGE2）、前列腺素F2α（PGF2α）的表达。结果用药12 h后观察组宫颈Bishop评分升高幅度大于对照组（P〈0.05）。观察组72 h内促宫颈成熟总有效率、引产成功率均高于对照组（P〈0.05）。2组不良反应及并发症发生率比较差异无统计学意义。观察组中引产成功组PGE2、PGF2α浓度均高于引产失败组（P〈0.05）。结论控释地诺前列酮引产能达到米索前列醇引产相似的安全性,且引产效果更显著。

Objective To investigate the effect of controlled-release dinoprostone on odinopoeia in prolonged pregnancy. Methods 94 cases of prolonged pregnancy women selected in First People＇s Hospital in Pinghu City from January 2012 to November 2014 were randomly divided into two groups,47 cases in each group. The control group were given misoprostol to induce labour,while the observation group were given controlled-release dinoprostone to induce labour. The Bishop score,odinopoeia effect and adverse reactions were compared between two groups and expressions of prostaglandin E2（ PGE2） and PGF2α in deciduas of observation group were compared between induction success group and induction failure group.Results The Bishop score in observation group was higher than that in control group 12 h post-administration（ P〈0. 05）. The total efficiency of cervical ripening,the induction success rate in observation group were higher than those in control group（ P〈0. 05）. The adverse reactions and the incidence of complications between two group was not statistically significant. The PGE2 and PGF2α concentrations in induction success group were higher than those in induction failure group（ P〈0. 05）. Conclusion The controlled-release dinoprostone could achieve similar security of misoprostol in odinopoeia,but has more significant induction effect.