盐酸伊立替康联合顺铂方案对宫颈癌患者宫颈上皮组织Bcl-2及MACC1蛋白表达的影响

Effect of irinotecan hydrochloride combined with cisplatin on Bcl-2 and MACC1 protein expressions in cervical epithelial tissue of cervical cancer patients

目的探讨盐酸伊立替康联合顺铂方案对宫颈癌患者宫颈上皮组织B淋巴细胞瘤-2基因（B-cell lymphoma-2,Bcl-2）及结肠癌转移相关基因1（metastasis-associated in colon cancer-1,MACC1）蛋白表达的影响。方法选取2010年1月~2013年1月在上饶市人民医院妇产科接受治疗的100例宫颈癌患者为研究对象,所有患者均采用盐酸伊立替康联合顺铂方案化疗,对比患者化疗前后的临床效果及宫颈上皮组织中的Bcl-2和MACC1蛋白的表达。结果宫颈癌患者以盐酸伊立替康联合顺铂方案进行化疗后,临床总有效率占75.0%（75/100）。化疗后Bcl-2、MACC1的表达以及高表达率较化疗前均显著降低（均P〈0.05）。临床有效组中Bcl-2、MACC1在化疗后的高表达情况较化疗前显著降低（均P〈0.05）;临床无效组中Bcl-2、MACC1在化疗后的高表达情况较化疗前差异无统计学意义。结论采取宫颈癌患者以盐酸伊立替康联合顺铂方案进行化疗后,宫颈癌患者宫颈上皮组织中Bcl-2与MACC1的表达显著降低,临床效果明显。

Objective To investigate the effect of irinotecan hydrochloride combined with cisplatin on B-cell lymphoma-2（ Bcl-2） and metastasisassociated in colon cancer-1（ MACC1） protein expressions in cervical epithelial tissue of cervical cancer patients. Methods 100 patients with cervical cancer from January 2010 to January 2013 in Department of Obstetrics and Gynecology of Shangrao City People＇s Hospital were selected as objects. All patients were treated with irinotecan hydrochloride and cisplatin for combination chemotherapy. The clinical effect and the protein expressions of Bcl-2and MACC1 of cervical epithelial tissue were compared pre-and post-chemotherapy. Results The total efficiency was 75. 0%（ 75 /100） after cervical cancer patients were given irinotecan hydrochloride combined with cisplatin chemotherapy program. The expressions and high expression rates of Bcl-2and MACC1 post-chemotherapy were significantly lower than that pre-chemotherapy（ P 0. 05）. In clinically effective group,the high expression rates of Bcl-2 and MACC1 post-chemotherapy significantly reduced than pre-treatment（ P 0. 05）,and in clinical invalid group,the difference of the high expression rates of Bcl-2 and MACC1 had no statistically significant. Conclusion After combination chemotherapy with irinotecan hydrochloride and cisplatin on cervical cancer,the expression of Bcl-2 and MACC1 in cervical epithelial tissue significantly reduce,and the clinical efficacy is aignificant.