噻托溴铵联合福莫特罗对老年慢性阻塞性肺病患者外周血氧化应激产物及脂质过氧化物的影响

Effect of tiotropium bromide combined with formoterol on oxidative stress and lipid peroxidation in peripheral blood in elderly patients with chronic obstructive pulmonary disease

目的噻托溴铵联合福莫特罗对老年慢性阻塞性肺病患者外周血氧化应激产物及脂质过氧化物影响效果研究。方法选取衢州市人民医院呼吸科收治的老年慢性阻塞性肺病（chronic obstructive pulmonary disease,COPD）患者80例,根据治疗方案不同分为常规组及实验组。常规组在常规治疗基础上应用沙美特罗替卡松粉吸入剂2吸/次,2~3次/天,连用14 d;实验组应用噻托溴铵喷雾剂联合富马酸福莫特罗粉吸入剂2吸/次,2~3次/天,连用14 d。7 d为1个疗程,2个疗程结束后,比较2组患者治疗前后临床体征、血气水平、外周血氧化应激产物及脂质过氧化物、炎性因子水平变化情况。结果与常规组治疗后比较,实验组患者临床呼吸体征较常规组恢复时间较短（P〈0.05）,实验组血气水平、外周血氧化应激产物及脂质过氧化物、炎性因子水平较常规组明显降低（P〈0.05）。结论噻托溴铵联合福莫特罗可明显降低气道高反应性,抑制炎症反应,缓解临床症状。并且耐药性低、副作用小、临床疗效理想,可作为临床治疗的有效方案,并具有重要意义。

Objective To investigate effect of tiotropium bromide combined with formoterol on oxidative stress and lipid peroxidation in peripheral blood in elderly patients with chronic obstructive pulmonary disease. Methods 80 elderly patients with chronic obstructive pulmonary disease from our hospital were selected and divided into conventional group and experimental group,conventional group on the basis of conventional therapy was treated with salmeterol xinafoate and fluticasone propionate powder for inhalation with 2 suction per times,2-3 times per day for 14 d. Experimental group was treated with tiotropium bromide spray combined with formoterol fumarate powder for inhalation with 2 suction per times,2-3 times per day for 14 d. 7 d for a period of treatment,after 2 courses of the treatment,changes of clinical signs,blood gas levels,peripheral blood oxidative stress products and lipid peroxidation and inflammatory factors were compared before and after treatment. Results Compared with conventional group,the recovery time were shorter（ P〈0. 05）,and blood gas levels,peripheral blood oxidative stress products and lipid peroxidation,inflammatory factors were lower（ P〈0. 05）.Conclusion Tiotropium bromide combined with formoterol can significantly reduce airway hyperresponsiveness,inhibit inflammation,relieve clinical symptoms. And the drug resistance is low,the side effect is small,the clinical curative effect is ideal,may be the clinical treatment effective plan,and has the vital significance.