小剂量利尿剂联合大黄蛰虫丸对慢性肾功能衰竭患者血清睾酮、胱抑素C、瘦素及β2微球蛋白水平影响研究

Effect of small dose of diuretics combined with Dahuang zhechong pill on testosterone,Cystatin C,leptin and β2 microglobulin in serum in patients with chronic renal failure

目的探究小剂量利尿剂联合大黄蛰虫丸对慢性肾功能衰竭患者血清睾酮、胱抑素C(cystatin C,Cys C)、瘦素及β2微球蛋白(β2-microglobulin,β2-MG)水平影响。方法收集肾内科患者69例,随机为治疗组(n=35)与对照组(n=34)。对照组给予氢氯噻嗪片,治疗组在此基础上服用大黄蛰虫丸。所有患者均治疗3个月。治疗结束后比较2组患者血清睾酮、胱抑素C、瘦素及β2微球蛋白水平。结果治疗后2组血清睾酮升高(P<0.05),Cys C、瘦素、β2-MG水平降低(P<0.05);与对照组相比,治疗组血清睾酮较高(P<0.05),Cys C、瘦素、β2-MG水平降低(P<0.05)。结论小剂量利尿剂联合大黄蛰虫丸治疗慢性肾功能衰竭疗效显著,其机制可能于升高患者血清睾酮水平,降低血清Cys C、瘦素及β2-MG水平有关。

Objective To explore effect of small dose of diuretics combined with Dahuangzhechong pill on testosterone,Cystatin C（ Cys C）,leptin and β2 microglobulin（ β2-MG） in serum in patients with chronic renal failure. Methods 69 cases of kidney disease patients were collected and divided into two groups. Testosterone,Cystatin C,leptin and β2 microglobulin in serum were compared before and after the treatment. The control group was given hydrochlorothiazide tablets,treatment group was given Dahuangzhechong pill based on the control group. All patients were treated for 3 months.Results After treatment,levels of testosterone elevated（ P〈0. 05）,Cys C,leptin and β2 microglobulin decreased（ P〈0. 05） in the two groups compared with before treatment; Compared with the control group,level of testosterone was higher（ P〈0. 05）,levels of Cys C,leptin and β2-MG were lower（ P〈0. 05）. Conclusion Low dose diuretics combined with Dahuang Zhechong pill has good effect in treatment of chronic renal failure curative.The mechanism may be related to elevate serum testosterone levels and reduce serum Cys C,leptin and β2-MG level in patients.