盐酸纳美芬辅助治疗对创伤性休克患者血清NO、内皮素及肌钙蛋白I水平影响研究

Effect of nalmefene hydrochloride adjuvant therapy on serum NO,endothelin and cardiac troponin I in patients with traumatic shock

目的探讨盐酸纳美芬辅助治疗对创伤性休克患者血清一氧化氮(nitric oxide,NO)、内皮素(endothelin,ET)、及心肌肌钙蛋白I(cardiac troponin I,c Tn I)的影响。方法收集急诊外科收治的创伤性休克患者48例,随机分为对照组和实验组,每组各24例,在常规抗休克治疗的基础上,对照组患者给予纳洛酮治疗,实验组患者给予盐酸纳美芬治疗,治疗结束后,对所有患者的血清NO、ET、c Tn I水平进行检测。结果治疗后,与对照组比较,实验组患者的血清NO水平较低(P<0.05);实验组患者的血清ET水平较低(P<0.05);实验组患者血清c Tn I水平较低(P<0.05)。结论盐酸纳美芬辅助治疗能够显著降低创伤性休克患者血清NO、ET及Tn I水平,控制休克病情发展,防止心肌损伤。

Objective To analyse effect of nalmefene hydrochloride adjuvant therapy on serum nitric oxide（ NO）,endothelin（ ET） and cardiac troponin I（ c Tn I） in patients with traumatic shock. Methods 48 patients who were diagnosed with traumatic shock were collected. All patients were randomly divided into experimental group and control group,24 cases in each group. On the basis of conventional anti shock treatment,the control group were treated with naloxone,the patients in experimental group received nalmefene hydrochloride treatment,after treatment,the serum levels of NO,endothelin and cardiac troponin I were detected in all patients. Results After treatment,compared with control group,the serum level of NO was lower in experimental group（ P〈0. 05）; the serum level of ET was lower in experimental group（ P〈0. 05）; the serum level of c Tn I was lower in experimental group（ P〈0. 05）. Conclusions Nalmefene hydrochloride adjuvant therapy could significantly reduce the serum levels of NO,ET and c Tn I in patients with traumatic shock,control the development of the disease,prevent myocardial injury.