参芪扶正注射液对心衰患者外周血AngⅡ、ET-1影响及临床疗效研究

Effect of Shen Qi Fu Zheng injection on peripheral blood AngⅡ,ET-1 levels and clinical curative effect in patients with congestive heart failure

目的探讨参芪扶正注射液对心衰患者血管紧张素Ⅱ(angiotensin II,AngⅡ)、内皮素-1(Human endothelin 1,ET-1)及临床疗效的影响。方法收集收治的慢性心力衰竭患者52例,随机分为对照组和实验组,每组各26例,对照组患者给予常规西药治疗,实验组在对照组基础上给予参芪扶正注射液治疗,治疗结束后,对所有患者的血浆AngⅡ、ET-1水平、心功能及临床疗效情况进行检测。结果治疗后,与对照组比较,实验组患者血浆AngⅡ水平较低(P<0.05);实验组患者的血浆ET-1水平较低(P<0.05);实验组患者的左室射血分数(left ventricular ejection fraction,LVEF)、心输出量(cardiac output,CO)以及每搏输出量(stroke volume,SV)水平较高,左室舒张末期内径(left ventricular end diastolic diameter,LVED)水平较低(P<0.05);实验组患者的有效率较高(χ2=4.457,P<0.05)。结论参芪扶正注射液能够显著降低心衰患者外周血AngⅡ、ET-1水平,改善心功能,提高临床疗效。

Objective To analysis effect of Shen Qi Fu Zheng injection on peripheral blood angiotensin II（ AngⅡ）,endothelin-1（ ET-1） levels and clinical curative effect in patients with congestive heart failure. Methods 52 patients who were diagnosed with chronic heart failure were collected. All patients were randomly divided into experimental group and control group,26 cases in each group. Patients in the control group received conventional western medicine treatment,patients in the experimental group were given Shen Qi Fu Zheng injection on the basis of control group treatment,after the treatment,the plasma levels of AngⅡ and ET-1,cardiac function and clinical efficacy were detected in all patients. Results After treatment,compared with control group,the plasma levels of AngⅡ was lower in the experimental group（ P〈0. 05）; the plasma levels of ET-1 was lower in the experimental group（ P〈0. 05）; the LVEF,CO and SV levels were higher,and the LVED level was lower in the experimental group（ P〈0. 05）; the effective rate of patients in the experimental group was higher（ P〈0. 05）. Conclusion The Shen Qi Fu Zheng injection can significantly reduce the plasma AngⅡ and ET-1 levels in patients with congestive heart failure,improve heart function and clinical curative effect.