丹参酮胶囊对全髋关节置换术后隐性出血的影响

Clinical effect of Danshentong capsule on invisible blood loss after total hip arthroplasty postoperative

目的观察研究中药丹参酮胶囊在髋关节置换术后隐性出血预防中的临床效果。方法选取苍南县人民医院2011年1月~2013年3月收治诊断为股骨头坏死并行髋关节置换术的患者共90例,按随机数字表法分为观察组和对照组,每组各45例,对照组给予低分子肝素常规西药预防术后隐性出血,观察组给予中药丹参注射液预防术后隐性出血,随访并记录2组患者相关指标变化情况。结果观察组患者术后3 d和7 d血红蛋白为（112.20±16.17）、（124.79±11.53）g/L,均优于对照组（94.84±14.93）、（103.52±10.62）g/L（P〈0.05）;观察组患者术后3d和7d血小板值为（258.31±32.95）、（242.16±31.06）×109/L,优于对照组（225.14±30.48）、（214.95±28.68）×109/L（P〈0.05）;观察组患者术后隐性失血量（420.59±53.96）,低于对照组（868.05±65.37）U/m L（P〈0.05）;观察组术后不良反应比例为6.67%,低于对照组26.67%（P〈0.05）。结论丹参酮胶囊在髋关节置换术后隐性出血预防中的临床效果确切,无明显不良反应,值得临床进一步研究和应用。

Objective To observe clinical effect of Danshentong capsule on invisible blood loss after total hip arthroplasty postoperative. Methods90 cases were randomly divided into observation group and control group,which were chosen from January 2011 to March 2013,45 cases in each group.Control group received low molecular weight heparin for prevention invisible blood loss,postoperative. Observation group were given Danshentong capsule for prevention invisible blood loss postoperative. Changes of related indicators were followed up and recorded. Results Hemoglobin were（ 112. 20 ± 16. 17）,（ 124. 79 ± 11. 53） g/L of observation group 3 and 7 days postoperation,were higher than control group（ 94. 84 ± 14. 93）,（ 103. 52± 10. 62） g / L（ P〈0. 05）. Patients in observation group 3 and 7 days platelet values（ 258. 31 ± 32. 95）,（ 242. 16 ± 31. 06） × 10^9/ L,than control group（ 225. 14 ± 30. 48,214. 95 ± 28. 68） × 10^9/ L（ P〈0. 05）. Patients in observation group hidden hemorrhage（ 420. 59 ± 53. 96）,lower than control group（ 868. 05 ± 65. 37） U / m L（ P〈0. 05）. Postoperative adverse reactions observed ratio of 6. 67% in observation group,lower than control group26. 67%（ P〈0. 05）. Conclusion Danshentong capsule in hip replacement surgery occult bleeding prevention clinical exact effect,no significant side effects,is worthy of further research and application.