牙痛宁酊辅助根管植入对患者龈沟液内IL-8、CD4及HSP70水平的影响

Effect of Yatongning tincture root canal implantation on IL-8,CD4 and HSP70 levels in gingival crevicular fluid of patients with periodontitis

目的探究牙痛宁酊辅助根管植入对牙周炎患者血清白细胞介素-8（interleukin 8,IL-8）、白细胞分化抗原4（cluster of differentiation 4,CD4）及热休克蛋白70（heat shock protein 70,HSP70）水平影响。方法收集2013年12月~2015年9月浙江省余姚市第二人民医院口腔科收治的牙周炎患者64例,根据治疗方法不同分为对照组和治疗组,治疗组33例,对照组31例,2组患者均实施根管植入治疗,治疗组在此基础上实施速效牙痛宁酊治疗方案,治疗结束后对比分析2组患者临床疗效、疼痛发生率、IL-8、CD4及HSP70水平。结果治疗组临床总有效率为96.97%（32例）,显著高于对照组的80.65%（31例）（χ2=4.373,P〈0.05）。治疗组疼痛发生率为30.30%（10例）,显著低于对照组的58.06%（18例）（χ2=5.006,P〈0.05）。治疗后,2组血清IL-8水平均明显升高,CD4、HSP70水平显著降低（P〈0.05）,与对照组相比,治疗组血清IL-8水平显著升高,CD4、HSP70水平显著降低（P〈0.05）。结论牙痛宁酊辅助根管植入提高根管治疗效果,缓解牙组织损伤,改善手术后患者疼痛。

Objective To explore the effect of Yatongning tincture root canal implantation on interleukin 8（ IL-8）,cluster of differentiation 4（ CD4） and heat shock protein 70（ HSP70） in in gingival crevicular fluid of patients with periodontitis. Methods 64 patients with periodontitis from December 2013 to September 2015 in stomatology department of Yuyao Second People＇s Hospital were selected and according to the different treatment methods divided into treatment group and control group,33 cases in treatment group,31 cases in control group. Patients received root canal implantation in two groups,the treatment group received Yatongning tincture root canal implantation on the basis of control group. The clinical curative effect,incidence of pain,IL-8,CD4 and HSP70 levels were compared between two groups. Results The clinical curative effect of treatment group was 96. 97%（ 32 cases）,which was higher than 80. 65%（ 31 cases） of control group（ χ2= 4. 373,P〈0. 05）. The pain incidence of treatment group was 30. 30%（ 10 cases）,which was higher than 58. 06%（ 18 cases） of control group（ χ2= 5. 006,P〈0. 05）. After treatment,the IL-8 levels were higher and CD4,HSP70 levels were lower in two groups than those pre-treatment（ P〈0. 05）,compared with control group,the IL-8 levels were higher and CD4,HSP70 levels were lower in treatment group（ P〈0. 05）. Conclusion Yatongning tincture root canal implantation could enhance the clinical efficacy,relieve tooth tissue damage and improve the post-operative pain in patients.