喘平滴丸主要药效学试验研究

Primary Pharmacodynamic Study on Chuanping Dropping Pills

目的:研究新药喘平滴丸的平喘、镇咳、祛痰作用。方法:采用组胺-乙酰胆碱引喘法、卵清蛋白致敏法、肺溢流实验法、豚鼠气管螺旋条法、豚鼠肺条法、小鼠氨水及枸橼酸引咳法和小鼠酚红祛痰法考察平喘滴丸的平喘镇咳祛痰作用。结果:喘平滴丸能显著延长组胺-乙酰胆碱诱发豚鼠哮喘反应的潜伏期;显著降低卵清蛋白致敏豚鼠哮喘的反应级并延长其引喘潜伏期;显著抑制由组胺引起的豚鼠肺溢流量增加;减轻组胺引起的豚鼠离体气管平滑肌和肺条收缩;减少氨水及枸橼酸引发小鼠咳嗽反应次数;增加小鼠气管内酚红排泌量。结论:喘平滴丸具有一定的平喘、镇咳、祛痰的功效。

Objective： To study the antitussive,antiasthmatic,and expectorant effects of Chuanping dropping pills. Methods： Histamine-acetylcholine induced asthma,ovalbumin sensitization,pulmonary overflow,spiral strip trachea of guinea pig,lung strip of guinea pig,ammonia water or citric acid induced cough of mice,and phenol red expectoration of mice were carried out. Results： Chuanping dripping pills significantly prolonged the incubation induced by histamine-acetylcholine,reduced the reaction stage of ovalbumin sensitization of guinea pig with asthma,inhibited the increase of pulmonary overflow on histamine induced asthma,reduced the contraction of smooth muscle and lung strip by histamine induced asthma on guinea pig,reduced cough times on ammonia or citrate acid caused mice,and increased the output on mice tracheal phenol red. Conclusions： Chuanping dropping pills have significant effect on antitussive,antiasthmatic and expectorant actions.