高分辨磁共振成像评价他汀治疗逆转颈动脉粥样硬化斑块研究进展

Study Progress of High Resolution MRI Evaluation in Regression of Carotid Atherosclerosis Induced by Statins Therapy

动脉粥样硬化斑块破裂继发血栓形成可引起急性心脑血管事件,严重威胁人类健康。而他汀治疗可延缓甚至逆转动脉粥样硬化斑块进展,但目前临床上缺少评价他汀治疗对斑块影响的无创性影像检查技术。高分辨磁共振成像技术(high-resolution magnetic resonance imaging,HR-MRI)作为一项新兴组织成像技术,具有良好的组织一致性,能够准确分析动脉粥样硬化斑块负荷,判定及定量分析斑块内各组分(包括纤维帽、富含脂质核心、钙化及出血等),通过选择超小超顺磁性氧化铁作为对比剂还可以评价斑块内炎症水平。本文就HR-MRI评价他汀治疗逆转颈动脉粥样硬化斑块进展做一简要综述。

Atherosclerotic plaque rupture with subsequent thrombosis could cause acute coronary or cerebrovascular events, which severely endangers human being＇s health. Statins therapy could postpone and even reverse the progress of the formation of atherosclerotic plaque, however, there were no available no invasive imaging techniques to evaluate the effects of statins therapy on atherosclerotic plaques. As a newly emerging imaging technology, high resolution magnetic resonance imaging（HR-MRI） has good histological consonance and could accurately analyze carotid atherosclerotic plaque burden, and determine and quantitatively analyze tissue compositions of plaques including fibrous cap, liquid rich necrotic core（LRNC）, calcification, intraplaque hemorrhage etc. Ultrasmall superparamagnetic iron oxide was used as contrast agent to evaluate the infl ammation level in the plaques with histological validation. This review summarizes the value of HR-MRI on evaluating regression of carotid atherosclerosis induced by statins therapy.