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胞外信号调控激酶(ERK)信号通路与抑郁症 被引量：8

Extracellular Signal Regulated Kinase(ERK) Signaling Pathway and Depression
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摘要 胞外信号调控激酶(extracellular signal-regulated kinase,ERK)信号通路对神经细胞的生长、增殖、分化和存活起关键调节作用,并且对脑内突触可塑性和学习记忆有重要影响,因此ERK信号通路逐渐成为抗抑郁机制的研究热点。该文综述了近年来ERK信号通路在抑郁症发生和治疗方面的作用和机制,供同行参考。 The extracellular signal regulated kinase（ERK） signal pathway plays a key role in the growth,proliferation,differentiation and survival of neurons and has important effects on synaptic plasticity and learning and memory in the brain. Therefore,ERK signaling pathway has become a hot research topic in the research of anti-depression mechanism. This paper reviews the role and mechanism of ERK signaling pathway in the pathogenesis and treatment of depression in recent years.
作者 李牧函 余冰颖 刘屏
机构地区 解放军总医院临床药理研究室 北京中医药大学 河北北方学院
出处 《神经药理学报》 2015年第1期38-44,共7页 Acta Neuropharmacologica
基金 国家自然科学基金资助(No.81173430)
关键词 胞外信号调控激酶(ERK) 信号通路 抑郁症 extracellular signal regulated kinase（ERK） signaling pathway depression
分类号 R964 [医药卫生—药理学]
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参考文献43

  • 1Maurizio Popoli,Nicoletta Brunello, Jorge Perez, et al. Second messenger-regulated protein kinases in the brain: their functional role and the action of antidepressant drugs [J]. J Neurochem, 2000,74 (I): 21-33.
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  • 4Sabrina Davis, Peter Vanhoutte, Christiane Pages, et al. The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo [J]. J Neurosci, 2000,20 (12): 4563-4572.
  • 5Raphaela Fritsche-Guenther, Franziska Witzel, Anja Sieber,et al. Strong negative feedback from Erk to Raf confers robustness to MAPK signaling [J]. Mol Syst Biol, 2011,7:489.
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  • 8Yuan Pei-xiong, Zhou Ru-lun, Wang Yun, et al. Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia [J]. J Affect Disord, 2010,124 (1-2): 164-169.
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二级参考文献60

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  • 9Chambard JC,Lefloch R,Pouysségur J,et al.ERK implication in cell cycle regulation[J].Biochim Biophys Acta,2007,1773(8):1299-1310.
  • 10Duman CH,Schlesinger L,Kodaman M,el at.A role for MAP kinase singaling in behavioral models of depression an antidepressant treatment[J].Biol Psychiat,2007,61(5):661-670.

共引文献47

同被引文献70

引证文献8

二级引证文献109

神经药理学报
2015年 第1期

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