FGFR4 mRNA在我国南方地区肺腺癌组织中的表达及其临床意义

FGFR4 mRNA expression in lung adenocarcinoma of south China area

目的 :探讨FGFR4 mRNA在我国南方地区肺腺癌组织中的表达以及与肺腺癌患者术后生存和预后的相关性。方法 :以实时荧光定量RT-PCR检测我国南方地区126例肺腺癌和正常肺组织中FGFR4 mRNA的表达量;应用Kaplan-Meier生存分析法分析FGFR4 mRNA的表达高低与肺腺癌患者术后生存时间的相关性。结果:实时荧光定量RT-PCR检测126例肺腺癌组织中FGFR4 mRNA相对表达量,发现癌组织中FGFR4 mRNA表达明显下调,两组比较有统计学意义(P﹤0.0001)。术后生存时间在高表达FGFR4 mRNA组的肺腺癌患者中比低表达FGFR4 mRNA组肺腺癌患者明显延长,差异具有统计学意义(P<0.05)。结论 :FGFR4 mRNA的表达与我国南方地区肺腺癌的发生和预后有一定的相关性,肺腺癌患者中FGFR4 mRNA表达下调,而FGFR4 mRNA高表达的肺腺癌患者可能有更好的生存期。

Objective：To investigate the expression of FGFR4 m RNA in lung adenocarcinoma tissues and its association with prognosis. Methods：The quantitative expression of FGFR4 m RNA in 126 lung adenocarcinoma tissues and normal lung tissues in south China area were detected by real-time fluorescence quantitative-PCR,and the relationship between the quantitative expression of FGFR4 m RNA in lung adenocarcinoma and the prognosis were analyzed. Results：The expression of FGF4 m RNA in lung adenocarcinoma was significantly higher than that in normal lung tissues（P〈0.0001）. The survival time of patients with lung adenocarcinoma with higher expression of FGFR4 m RNA was significantly longer than those with lower expression level of FGFR4 m RNA（P〈0.05）. Conclusion：FGFR4 m RNA expression in lung adenocarcinoma of south China area was significantly downregulated than that in tumor-adjacent normal lung tissue. Postoperative survival time of patients with lung adenocarcinoma in high FGFR4 m RNA expression was significantly longer than that with low expression.