头孢曲松钠联合苄星青霉素治疗快速血浆反应素高滴度妊娠梅毒的疗效分析

Analysis of therapeutic effect of ceftriaxone sodium combined with benzathine penicillin treatment of rapid plasma reagin high titer of pregnant syphilis

目的 :探讨头孢曲松钠联合苄星青霉素治疗快速血浆反应素(rapid plasma reagin,RPR)高滴度(≥1∶16)的妊娠梅毒患者的疗效。方法:回顾性分析本院诊治的RPR高滴度妊娠梅毒患者65例,根据治疗方法不同分为治疗组33例、对照组32例。其中治疗组给予头孢曲松钠联合苄星青霉素治疗,对照组给予苄星青霉素治疗,比较两组患者治疗后的临床效果和妊娠结局。结果:随访至治疗后的第12个月时,治疗组中妊娠梅毒患者有26例血清RPR转阴,痊愈率为78.79%;对照组中妊娠梅毒患者有17例血清RPR转阴,痊愈率为53.13%。两组妊娠梅毒痊愈率相比差异有统计学意义(P<0.05)。两组患者接受治疗后均未发生先天梅毒、死胎、低体重儿及新生儿死亡,对照组接受治疗后出现早产1例,妊娠结局无差异。结论:头孢曲松钠联合苄星青霉素治疗RPR高滴度妊娠梅毒效果较单一使用苄星青霉素显著,表现在血清RPR阴转时间缩短,转阴率高。

Objective：To observe the rapid plasma reagin change in pregnant syphilis patients treated with combination of ceftriaxone sodium and bicillin. Methods：Retrospective analysis was performed to 65 cases ivas performed the petients to diagnosis and treatment of pregnant syphilis patients in our department,according to the different treatment methods, the patints were divided into the treatment group of 33 cases,32 cases in the control group. The treatment group was treated with ceftriaxone sodium combined with benzathine penicillin treatment,and the control group received benzathine penicillin therapy,clinical effect and the pregnancy outcome after treatment were compared between two groups. Results：The cases of RPR negative conversion in the treatment group were 26,and the rate of RPR negative conversion was 78.79%,while that of the control group were 17（53.13%）,showing significant differences between two groups（P〈0.05）. Patients in the two groups after treatment didn＇t give birth to baby with congenital syphilis,stillbirth,low birth weight fetal and neonatal death,and in the control group after treatment 1 cases of premature delivery was reported. No difference showed in pregnancy outcome. Conclusion：Combined usages of cefiriaxone sodium and bicillin for treatment of pregnant syphilis patients with rapid plasma reagin high titer can apparently shorten the time of RPR negative conversion.