HD、HP+HD、HDF三种血液净化前后血清同型半胱氨酸水平及微炎性状态的变化

The change of serum levels of homocysteine and the micro inflammatory state after the treatment of HD,HP + HD and HDF

目的分析HD、HP+HD、HDF三种血液净化前后血清同型半胱氨酸(Hcy)水平及微炎性状态的变化。方法将180例维持血液透析患者随机分为A、B、C三组各60例,分别给予HD、HDF、HP+HD,对比血液净化前后Hcy变化及炎性状态变化。结果 C组治疗后2 h、6个月Hcy含量明显低于A、B两组,C组患者治疗后PTH、Leptin、β2-MG、TNF-α、IL-6较A组、B组明显降低,Hb、ALB明显高于A、B两组,差异具有统计学意义,P<0.05。结论对慢性肾功能衰竭患者采取HP+HD治疗,可降低患者Hcy含量,提高患者营养状况,改善机体微炎性状态。

Objective To analyze the changes of serum homocysteine （Hcy） level and micro inflammatory state in patients who received the treatment of HD, HP ＋ HD and HDF. Methods 180 cases of patients receiving maintenance hemodialysis were randomly divided into three groups （A, B and C）, 60 cases in each group. They were given the treatment of HDF, HD, and HP ＋ HD respectively, the changes of Hcy and micro inflammatory state were compared before and after blood purification. Results Two hours and 6 months after the treatment, the concentration of Hey in Group C was significantly lower than that in group A and B. However, the concentration of PTH, Leptin, [32 -MG, TNF-oc and IL-6 in group C were significantly lower than that in group A and B. Hb and ALB levels in group C were significantly higher than group A and B, the differences were statistically significant,P 〈 0. 05. Conclusions HP ＋ HD can reduce the Hey content of chronic renal failure patients, as well as improve the nutritional status and Micro inflammatory state of patients.