摘要
Wnt5a是非经典Wnt蛋白中具有代表性的蛋白,其介导的非经典Wnt信号具有调控细胞增殖、分化、迁移和极化的作用。近年来研究发现,Wnt5a及其介导的信号通路在调控牙源性干细胞方面起重要作用,其机制成为牙组织工程学研究热点,也为牙再生提供了新的思路。以下仅对Wnt5a及其介导的信号通路在牙源性干细胞方面的研究进展做一综述。
Wnt5a is a representative noncanonical Wnt molecule and the nocanonical Wnt signalling pathway induced by it regulates a variety of cellular functions,such as proliferation,differentiation,migration,adhesion and polarity. Recent studies have shown that Wnt5 a and its signaling pathways play a pivotal role in the regulation of dental mesenchymal stem cells（DMSCs）,whose mechanism has become a hot topic for tooth tissue engineering,providing a new way of thinking for dental tissue regeneration. In this paper,the new researches on Wnt5 a and its mediated signaling pathways in terms of dental stem cells were overviewed.
出处
《中国实用口腔科杂志》
CAS
2016年第2期121-124,共4页
Chinese Journal of Practical Stomatology
基金
贵州省科技支撑计划(黔科合SY字[2013]3041)
