术中瘤体破裂对腹膜后脂肪肉瘤预后的影响

Clinicopathological features and prognosis of retroperitoneal liposarcoma with tumor rupture during operation

目的分析术中瘤体破裂对腹膜后脂肪肉瘤预后的影响。方法收集2003年1月-2014年12月在我院接受腹膜后脂肪肉瘤切除术87例完整临床资料,根据术中瘤体是否破裂分组,其中术中瘤体破裂组23例,术中瘤体未破裂组64例,分析两组临床病理特点及预后差异。结果两组肿瘤分化程度(χ2=7.814,P=0.005)差异有统计学意义。单因素分析显示,瘤体破裂(χ2=12.637,P=0.000)、肿瘤分化程度(χ2=12.104,P=0.001)、手术方式(χ2=9.930,P=0.002)与腹膜后脂肪肉瘤预后相关。术中瘤体破裂组的1年、3年、5年生存率为73.9%、39.1%、21.7%;术中瘤体未破裂组为93.7%、59.4%、48.4%。结论术中瘤体破裂的腹膜后脂肪肉瘤患者预后较差。

Objective To analyze the clinicopathological features and prognosis of retroperitoneal liposarcoma with tumor rupture during operation. Methods Clinical data about 87 patients with retroperitoneal liposarcoma managed with surgery from January 2003 to December 2014 in our hospital were retrospectively analyzed and all patients were followed up. Of the 87 cases, the tumor of 23 patients ruptured during surgery, while the other 64 cases were not ruptured. The differences of clinicopathological features and prognosis between the two groups were analyzed. Results There was significant difference in tumor differentiation（χ2=7.814, P=0.005）, univariate analysis showed that tumor rupture（χ2=12.637, P=0.000）, tumor differentiation degree（χ2=12.104, P=0.001） and operative method（χ2=9.930, P=0.002） were positively correlated with survival time. The 1-, 3-, 5-year survival rate of ruptured tumor group and unruptured tumor group were 73.9%, 39.1%, 21.7% and 93.75%, 59.4%, 48.4%, respectively.Conclusion Retroperitoneal liposarcoma patients with ruptured tumor have poor prognosis.