载脂蛋白BmRNA编辑酶催化多肽3G抗乙肝病毒作用研究进展

Apolipoprotein B mRNA editing enzyme catalytic polypeptide 3G against hepatitis B virus

载脂蛋白B m RNA编辑酶催化多肽3G(apolipoprotein B m RNA editing enzyme catalytic polypeptide-like 3G,APOBEC3G)是一种天然抗病毒因子,目前研究证明其具有抗乙肝病毒的作用。它可能通过影响HBV DNA逆转录、诱导HBV DNA超突变、包装到HBV病毒粒子中、参与干扰素的抗病毒作用等方式起到抗乙肝病毒的作用。它为新型抗病毒药物的开发和机体天然免疫机制的研究开拓了新的方向,可能对未来的HBV防治提供新的线索并产生重要影响。

Apolipoprotein B m RNA editing enzyme catalytic polypeptide-like 3G（APOBEC3G） is a kind of natural anti viral factor, the present study has proved that it has the function of anti HBV. It can affect the reverse transcription of HBV DNA, induce HBV DNA super mutation, pack it into the HBV virus particles, participate in the antiviral effect of interferon and other ways to resist hepatitis B virus. It has opened up a new direction for the development of new antiviral drugs and the study of mechanism of natural immune system, which may provide new clues for the prevention and treatment of HBV in the future.