摘要
结核病是仅次于艾滋病的,在世界范围内由单一传染性病原体引起的重大感染性疾病。2013年,全球有900万人罹患结核病,其中包括55万名儿童,150万人死于该疾病。近些年,由于用药不严谨,新药研发速度缓慢,出现了一种新型的耐多药结核病,加大了结核病的防控难度。本文着眼于结核分枝杆菌耐药性这一领域,对一些常用抗结核药物的耐药机制、分枝杆菌外排泵基因调控机制等展开分析研究并进行综合论述。
Tuberculosis is,second to AIDS,the world＇s deadliest infectious disease caused by a single infectious agent.In 2013,9million people contracted tuberculosis worldwide.Of those,550 000 were children and 1.5million died.Over the past few years,new multi-drug-resistant tuberculosis（MDR-TB）has emerged because of drug overuse and slow development of new drugs,further hampering the prevention and control of tuberculosis.This review aims to analyze and comprehensively discuss the mechanisms by which Mycobacterium tuberculosis becomes resistant to commonly used antituberculosis drugs and the mechanisms that regulate the efflux pump genes of M.tuberculosis that allow it to become drug-resistant.
出处
《中国病原生物学杂志》
CSCD
北大核心
2016年第2期181-184,共4页
Journal of Pathogen Biology
关键词
结核分枝杆菌
耐药机制
耐药基因
突变
药物外排泵
综述
Mycobacterium tuberculosis
mechanisms of drug resistance
drug resistance genes
mutation
drug efflux pump
review
