鸦胆子油乳注射液联合化疗治疗晚期胃癌的疗效及安全性Meta分析

Meta-analysis on efficacy and safety of Brucea javanica oil emulsion injection combined with chemotherapy for patients with advanced gastric carcinoma

通过计算机检索Cochrane library,Pub Med,Medline,中国知网数据库、中国生物医学文献数据库、中文科技期刊全文数据库,检索时间从数据库建库至2014年6月,纳入鸦胆子油乳注射液联合化疗治疗晚期胃癌的随机对照试验(randomized controlled trials,RCTs)7项。评价纳入研究的质量并提取资料,由2名研究员分别独立提取数据和进行文献质量评价,并用Rev Man 5.2软件进行统计分析。系统评价鸦胆子油乳联合化疗治疗晚期胃癌的临床疗效和安全性。Meta分析结果显示,与单纯化疗方案相比,鸦胆子油乳注射液联合化疗方案可以提高晚期胃癌患者的客观反应率(RR=1.43,P<0.001)、降低中性粒细胞减少(RR=0.56,P<0.001)、血小板减少(RR=0.64,P=0.02)及恶心、呕吐发生率(RR=0.66,P=0.002),但未能明显改善生活质量(RR=1.36,P=0.07)。该研究提示鸦胆子注射液联合化疗治疗晚期胃癌具有增效、减毒作用,具有一定的应用前景。

Eligible studies were searched in Cochrane library,Pubmed,Medline,CBM,CNKI and VIP databases from establishment to June 2014. Two researchers independently identified 7 randomized controlled trials（ RCTs） and extracted data of Brucea javanica oil emulsion injection combined with chemotherapy. Based on the published studies,the researchers analyzed them by Rev Man 5. 2software and investigated the efficacy and safety of Brucea javanica oil emulsion injection combined with chemotherapy for patients with advanced gastric cancer by Meta analysis. Meta analysis showed that,compared with the simple chemotherapy,Brucea javanica oil emulsion injection combined with chemotherapy could increase objective response rate by 43%（ RR = 1. 43,P 〈0. 001）. In addition,the incidence of neutropenia（ RR = 0. 56,P 〈0. 001）,thrombocytopenia（ RR = 0. 64,P = 0. 02）,nausea,vomit（ RR = 0. 66,P = 0. 002） decreased in these patients. However,the quality of life was not improved significantly in gastric carcinoma patients with combined therapy（ RR = 1. 36,P = 0. 07）. The paper suggested Brucea javanica oil emulsion injection combined with chemotherapy could increase efficacy and safety,which might be a promising therapy for patients with advanced gastric cancer.