2998例男性患者解脲脲原体、淋病奈瑟菌和沙眼衣原体感染调查分析

Analysis of infections caused by Ureaplasma urealyticum,Neisseria gonorrhoeae and Chlamydia trachomatis in 2998 male patients

目的检测我院门诊男性患者解脲脲原体(Ureaplasma urealyticum,UU)、淋病奈瑟菌(Neisseria gonorrhoeae,NG)、沙眼衣原体(Chlamydia trachomatis,CT)感染现状,为此类患者的临床诊治提供实验室依据。方法收集2013年4月至2015年4月我院门诊男性患者首段尿液标本2998份,采用实时荧光核酸恒温扩增技术检测标本中的CT、NG和UU,并对患者年龄和诊断进行分析。结果男性患者首段尿中UU、CT、NG阳性率依次降低,分别为18.4%,9.5%和2.0%,感染类型以单独UU为主,其次是单独CT和混合UU+CT,分别占15.3%、6.0%和2.9%。20岁以下年龄段阳性率最高,50岁以上阳性率较低,但样本量较少。尿道炎和体检患者CT阳性率较高,不育症患者NG阳性率最高。结论 CT、NG、UU是我院门诊男性泌尿生殖道感染的重要病原体,20岁以下人群阳性率最高,宜加强监测。

Objective To analyze the infection status of Ureaplasma urealyticum （UU）, Neisseria gonorrhoeae （NG） and Chlamydia trachomatis （CT） in male patients so as to provide laboratory basis for diagnosis and treatment. Methods A total of 2998 cases first catch urine specimens were collected from the male patients attending the outpatient department of our hospital from Apt 2013 to Apr 2015, then the simultaneous isothermal amplification assay was applied to detect the three species of pathogens, the age and diagnosis of patients were also analyzed. Results The positive rates ofUU, CT and NG were 18.4%, 9.5% and 2.0% respectively. The main infectious type is the single UU infection （15.3%）, then the single CT and the CT plus UU infection （6.0%, 2.9%）. As positive rate of infection concerned, patients of less than 20 years old was the highest, that of patients of more than 50 years old was lower, but the size of samples was too small. The positive rate of CT in patients who got urethritis and just went for routine examination was higher; the prevalence of NG in patients with infertility was the highest. Conclusion CT, NG and UU are the important causes for male genitourinary tract infection, the detection of urine pathogens in young patients of less than 20 years old should be focused on because of the highest UU, NG and CT prevalence rate.