中国先天性心脏病危险因素的Meta分析

Risk factors of congenital heart diseases in China:a Meta-analysis

目的运用Meta分析方法,分析中国先天性心脏病的危险因素,以期为中国先天性心脏病的病因研究和预防提供参考。方法通过中国生物医学文献、知网、维普、万方等中文文献数据库检索2005~2015年相关文献,对文献进行筛选、信息提取、质量评价,应用Stata12.0软件进行合并分析。结果共纳入37篇文献;包括全国20省（市、区）、病例组8 588例、对照组12 479例;纳入21个危险因素（5个孕前因素、16个孕期因素）。结论 21个危险因素包括4个孕前因素,15个孕期因素,尚不能确认危险因素2个。前3位的危险因素及其OR值和95%CI为：孕期糖尿病5.80（2.72~12.37）、孕期接触职业危险因素5.14（3.30~8.00）、孕前孕妇高龄4.96（1.45~16.97）,尚且不能认为是危险因素及其OR值和95%CI为：孕前体质指数高1.32（0.99~1.75）,孕期住所离马路近1.36（0.50~3.71）。

Objective To analyze the risk factors of congenital heart disease（CHD）in China by using the meta-analysis method to provide reference for etiology study and prevention of CHD.Methods The Chinese literature database such as CBM,VIP,CNKI,Wan Fang were retrieved from 2005 to 2015for collecting the related literatures,then the collected literatures were screened,performed the information extraction,quality evaluation and merged analysis by using the Stata12.0software.Results In this study,37 articles were included,including 20provinces（municipalities and autonomous regions）,8 588 cases in the case group and 12 479 cases in the control group;a total of 21 risk factors（5pre-pregnant factors and 16 gestational factors）were included.Conclusion All 21 risk factors include 4pre-pregnancy factors,15 gestational factors and 2factors which not be verified.The top 3risk factors and their ORvalues with 95%CI were gestational diabetes 5.80（2.72-12.37）,contacting the occupational risk factors5.14（3.30-8.00）,advanced age before pregnancy 4.96（1.45-16.97）.Not considering to be as the risk factors and their ORvalue with 95%CI are high body mass index before pregnancy 1.32（0.99-1.75）,living near street during pregnancy 1.36（0.50-3.71）.